Detailed information of TA system TA196012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2581222..2581711
• Replicon: chromosome
• Accession: NZ_CP071248
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7009

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: BLI009_RS11425
• Protein ID: WP_060620047.1
• Coordinates: 2581222..2581491 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4R0VXI9
• Locus tag: BLI009_RS11430
• Protein ID: WP_060620048.1
• Coordinates: 2581475..2581711 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI009_RS11410	2578445..2579167	-	723	WP_060620046.1	hypothetical protein	-
BLI009_RS11415	2579232..2580188	-	957	WP_032744820.1	A/G-specific adenine glycosylase	-
BLI009_RS11420	2580209..2580871	+	663	WP_131223048.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
BLI009_RS11425	2581222..2581491	-	270	WP_060620047.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BLI009_RS11430	2581475..2581711	-	237	WP_060620048.1	ribbon-helix-helix domain-containing protein	Antitoxin
BLI009_RS11435	2582294..2583007	-	714	WP_082247953.1	4'-phosphopantetheinyl transferase superfamily protein	-
BLI009_RS11440	2583018..2584208	-	1191	WP_206648674.1	MFS transporter	-
BLI009_RS11445	2584371..2585558	-	1188	WP_206648675.1	carboxylate--amine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10340.17 Da
• Isoelectric Point: 10.3382

>T196012 WP_060620047.1 NZ_CP071248:c2581491-2581222 [Bifidobacterium longum subsp. infantis]
MSWRIEIDKGVQRSMKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVA
HRSKVYKRC

Nucleotide

• Length: 270 bp

>T196012 NZ_CP094998:c3260100-3259705 [Synechocystis sp. PCC 6803]
GTGAAACTTTTGTTGGATACCCAGTGCTGGTTATGGTGGTTTACTGAGCCGGAAAAATTGAACGAAGATGCAATTTCCCA
GATCATAGATGAGACAAACGAAATATGGCTTTCTGTTGCCAGTATTTGGGAAATGTCAATTAAGACTTCCATCGGTAAAC
TGCCCTTGCCAGAAAATATTGACGACTACATTCTCAGTCGCATGGTGAAATTGGGTGCTGAGTTCCTGGACATTAAAACC
CGCCATGCCCTGCAAGTTGCGACATTGCCCCTACATCACCGTGATCCGTTTGACAGAATTATCATTGCCCAGGCACAAAC
AGAAAATATGCTGCTAATTAGTGCAGATTCAATGTTTAAAAATTATGGAGTCTCTTTGTTATGGGCGGGAGTATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8970.23 Da
• Isoelectric Point: 4.2821

>AT196012 WP_060620048.1 NZ_CP071248:c2581711-2581475 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLVLED

Nucleotide

• Length: 237 bp

>AT196012 NZ_CP094998:c3260390-3260112 [Synechocystis sp. PCC 6803]
ATGATCGGAGTTAGCGTTAATCCAGAGAAACTAGGATCCACTATGGAGACCGTCAATGTTGACCAAATAGAAATCAATCT
TCCTGAGCTTTTGTACAGTATCAAACCAGGGGAAGAAGTCATCGTTGCTGACCAGGGTATTCCCATTGCTAAGTTGGTTC
CTCTGCAAAGGCAAAAATCCGTGGATCGATGCTCCAGCTTAGGGGTAGATCGAGGATTATTTGTAGTGCCAGATGACTTT
AACGATCCTTTACCAAATGATATTTGGCCATTATCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A4R0VXI9