Detailed information of TA system TA196011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 2232998..2233518
• Replicon: chromosome
• Accession: NZ_CP071248
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7009

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: BLI009_RS09870
• Protein ID: WP_206649247.1
• Coordinates: 2233264..2233518 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: I3B069
• Locus tag: BLI009_RS09865
• Protein ID: WP_007051980.1
• Coordinates: 2232998..2233264 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI009_RS09830	2228289..2228606	+	318	WP_065436683.1	HigA family addiction module antidote protein	-
BLI009_RS09835	2228874..2229311	+	438	WP_165506826.1	hypothetical protein	-
BLI009_RS09840	2229388..2230932	+	1545	WP_065436685.1	hypothetical protein	-
BLI009_RS09845	2231037..2231414	+	378	WP_065436686.1	hypothetical protein	-
BLI009_RS09850	2231565..2231927	-	363	WP_065436761.1	hypothetical protein	-
BLI009_RS09855	2231991..2232413	-	423	WP_206648557.1	hypothetical protein	-
BLI009_RS09860	2232436..2232816	-	381	WP_206648558.1	hypothetical protein	-
BLI009_RS09865	2232998..2233264	+	267	WP_007051980.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BLI009_RS09870	2233264..2233518	+	255	WP_206649247.1	Txe/YoeB family addiction module toxin	Toxin
BLI009_RS09875	2233512..2234576	-	1065	WP_206648559.1	hypothetical protein	-
BLI009_RS09880	2234659..2235039	-	381	WP_206648560.1	hypothetical protein	-
BLI009_RS09885	2235050..2235598	-	549	WP_206648561.1	hypothetical protein	-
BLI009_RS09890	2235837..2236082	+	246	WP_007053507.1	hypothetical protein	-
BLI009_RS09895	2236171..2237847	+	1677	WP_077385842.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2194462..2298387	103925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-76)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9936.34 Da
• Isoelectric Point: 8.4862

>T196011 WP_206649247.1 NZ_CP071248:2233264-2233518 [Bifidobacterium longum subsp. infantis]
MLLCWTEDAWADYLYWQSQDRKTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCTLSA
KDHY

Nucleotide

• Length: 255 bp

>T196011 NZ_CP094998:c2514168-2513791 [Synechocystis sp. PCC 6803]
ATGCTACTGGACACCCACACGCTTTTGTGGTTTTTAGATAATGATATAAAACTACCATCACATCTCAAGAGTTTGATTGA
AGCCAAGCCAAAAGTTTATGTCAGCATTGTATCTCTCTGGGAGATTGCCATTAAACTCAACATCAACAAACTAAGGCTTA
ATTACGCTTTTACTGATCTAGAGAATTTACTTGCTGATCTCAATATTTCGGTTTTGAACATCACATGGCAACATTTGGAA
GCTTGTCGCAATTTGCCCTTGCATCATCGAGATCCTTTTGACCGTATGATTATTGCCCAGGCTCAGCAACATAATTTTTC
CGTCATTAGCAAAGACGAAAATTTCAAAAAATACAACGTTAATTTAATCTGGGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9922.13 Da
• Isoelectric Point: 4.3407

>AT196011 WP_007051980.1 NZ_CP071248:2232998-2233264 [Bifidobacterium longum subsp. infantis]
MTQAVAYSNFRANLKTYMRRVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLVEAGA

Nucleotide

• Length: 267 bp

>AT196011 NZ_CP094998:c2514390-2514169 [Synechocystis sp. PCC 6803]
ATGACAGACACCGCCCTACTAGAAAAGATCAATGCTCTCCCCGATGCCATGAAAATTGAAGTAGAACACTTTGTCGAATT
TCTGCTGACTAAGCAACCACCAGTCAGTCCAGTAACCAATGATGGACAAAAAAAATATCGTCAAGCAGGTGTTCTAAAGG
GGAAAATTTGGATGGCAGATGACTTTGATGCTCCTTTGGAAGAAATGCAGGAGTATATGTAA

Structures

Antitoxin

• AlphaFold DB: I3B069