Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 2053107..2053743 Replicon chromosome
Accession NZ_CP071248
Organism Bifidobacterium longum subsp. infantis strain JCM 7009

Toxin (Protein)


Gene name mazF Uniprot ID A0A4R0T054
Locus tag BLI009_RS09050 Protein ID WP_065436064.1
Coordinates 2053387..2053743 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K9C8D0
Locus tag BLI009_RS09045 Protein ID WP_025221547.1
Coordinates 2053107..2053400 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLI009_RS09020 2048255..2050933 - 2679 WP_193641406.1 alanine--tRNA ligase -
BLI009_RS09025 2051062..2051298 - 237 WP_007053386.1 hypothetical protein -
BLI009_RS09030 2051298..2051696 - 399 WP_007052133.1 DUF948 domain-containing protein -
BLI009_RS09035 2051841..2052515 - 675 WP_206648490.1 histidine phosphatase family protein -
BLI009_RS09040 2052746..2053033 + 288 Protein_1745 IS30 family transposase -
BLI009_RS09045 2053107..2053400 + 294 WP_025221547.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLI009_RS09050 2053387..2053743 + 357 WP_065436064.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BLI009_RS09055 2053921..2054523 - 603 WP_003829233.1 transglutaminase family protein -
BLI009_RS09060 2054628..2054984 - 357 WP_025299775.1 SdpI family protein -
BLI009_RS09065 2055075..2055560 + 486 WP_014483808.1 cytidine deaminase -
BLI009_RS09070 2055698..2056480 + 783 WP_206648491.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
BLI009_RS09075 2056660..2057286 - 627 WP_007052130.1 30S ribosomal protein S4 -
BLI009_RS09080 2057485..2058477 - 993 WP_206648492.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-53)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13231.08 Da        Isoelectric Point: 6.3014

>T196009 WP_065436064.1 NZ_CP071248:2053387-2053743 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLSLDDGPTGRLSAYDAGSVAWEINELYPGLLA

Download         Length: 357 bp

>T196009 NZ_CP094998:1659095-1659529 [Synechocystis sp. PCC 6803]
ATGAACAATGAAGTTATCCGGGTTGTAATTGATACGAATATCTGGATCAGTTTTCTAATTGGAAAAACTCTTCAAGGTTT
AAATCAAGCCATCATTGATAACCAAGTGGTCATTTTATTCAGTGACACTTTGTTTACTGAGCTGATGGAAGTATTACACC
ATCCTAAATTCAAAAAGTACTTTTCCGGAACAGCCATCCAAAATTTAATCGCACTGTTAAACGAAAAAGTTGAATTGGTT
GAAGTGAATCTTCATTTTGACAGTTATCGAGACAAAAAAGATAATTTCTTGCTGGATTTGGCAGTCTCAGGCAATGCAAA
TTATTTGGTGACGGGAGATAGTGACCTATTGACATTAAACCCATTTGACAATGTAGAAATTATCTCCTATCAACATTTTC
AAGCTATTATTTTAGCCATGATGGATAATCAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10836.28 Da        Isoelectric Point: 4.2896

>AT196009 WP_025221547.1 NZ_CP071248:2053107-2053400 [Bifidobacterium longum subsp. infantis]
MAIKEKATISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTPQ
IRDGAVILPEGWDDDED

Download         Length: 294 bp

>AT196009 NZ_CP094998:1658887-1659105 [Synechocystis sp. PCC 6803]
ATGCACTCATTGTCATCACTGGAATTTCCTGAGCTTAAAAGTGTTATTGCCCAATGTAATCTTGAAGAAAAACTTGAATT
ATTAGAACTTTTGGAAAAGGATACTTTTGGCACCAGATTTAACAAATTTTTAAATTCTGTCAAAACTGACGAATTAACCT
TAGAAGACATTACACAAGAAGTTGAATCGGTCCGGCAAGCTAATTATCATGAACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0T054

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9C8D0

References