Detailed information of TA system TA196008

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1931410..1931976
• Replicon: chromosome
• Accession: NZ_CP071248
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0L7BQL3
• Locus tag: BLI009_RS08465
• Protein ID: WP_029680114.1
• Coordinates: 1931683..1931976 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S2VZL2
• Locus tag: BLI009_RS08460
• Protein ID: WP_071477905.1
• Coordinates: 1931410..1931679 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI009_RS08430	1926521..1927654	-	1134	WP_206648445.1	IS1249 family transposase	-
BLI009_RS08435	1927947..1929224	+	1278	WP_193642223.1	IS256-like element ISBlo8 family transposase	-
BLI009_RS08440	1929564..1929704	+	141	WP_007056287.1	hypothetical protein	-
BLI009_RS08445	1930106..1930582	-	477	Protein_1627	histidine kinase	-
BLI009_RS08450	1930573..1930785	+	213	Protein_1628	hypothetical protein	-
BLI009_RS08455	1930780..1931173	+	394	Protein_1629	ABC transporter permease	-
BLI009_RS08460	1931410..1931679	+	270	WP_071477905.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BLI009_RS08465	1931683..1931976	+	294	WP_029680114.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BLI009_RS08470	1932034..1932494	+	461	Protein_1632	hypothetical protein	-
BLI009_RS08475	1932520..1932927	-	408	WP_193642259.1	hypothetical protein	-
BLI009_RS08480	1933102..1933303	-	202	Protein_1634	antitoxin VbhA family protein	-
BLI009_RS08485	1933517..1934158	+	642	WP_206648446.1	moaA protein	-
BLI009_RS08490	1934251..1934544	+	294	WP_206648447.1	hypothetical protein	-
BLI009_RS08495	1935344..1935974	+	631	Protein_1637	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1926521..1946976	20455
	-	flank	IS/Tn	-	-	1927923..1929224	1301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-88)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11160.90 Da
• Isoelectric Point: 9.7881

>T196008 WP_029680114.1 NZ_CP071248:1931683-1931976 [Bifidobacterium longum subsp. infantis]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Nucleotide

• Length: 294 bp

>T196008 NZ_CP094998:545250-545588 [Synechocystis sp. PCC 6803]
ATGAATATTTGGGTTGATGCTCAACTACCTCCAACATTGGCAGATTGGCTGTCGAGTAATTTTGATTTAGAGGCGTCAGC
TTTGAGGGATCTGGGATTACGGGATGCAAGAGACATTGAAATTTTTGATGCCGCACGAGTTGCCAACTCTGTAATCATGA
CAAAAGACAGCGACTTCGTTGATCTTGTATGTCGATTAGGAATACCACCTCAAATCATTTGGCTAACTTGCGGTAACGTT
ACGAATCGAAACTTACGTCGAATTCTCTCAAGTACTTTGCCACAGGCTCTGGAAAAACTGCAAGCAGGCGAAATTATCAT
AGAAATCAGCAACTCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9888.18 Da
• Isoelectric Point: 4.7872

>AT196008 WP_071477905.1 NZ_CP071248:1931410-1931679 [Bifidobacterium longum subsp. infantis]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGRPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT196008 NZ_CP094998:545029-545253 [Synechocystis sp. PCC 6803]
ATGAATAGCTTACTGTCTCGCATTACCCAAACCCCCGGTCAGTGTGGTGGTCGTCCTTGTATTCGAGGGATGAGGATTCG
AGTGAGCGACATCCTAGAAATGTTAGCTGAGAATGTTAGCACCTCTGAGATTTTAGAGGACTTTCCAGACCTAGAAATGG
CCGATATTCAGGCTTGTCTAGTGTTTGCTGCACGGCGGACTGATTTTTCCCGGTTGACGGCATGA

Structures

Toxin

• AlphaFold DB: A0A0L7BQL3

Antitoxin

• AlphaFold DB: A0A1S2VZL2