Detailed information of TA system TA196007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1673225..1674078
• Replicon: chromosome
• Accession: NZ_CP071248
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BLI009_RS07210
• Protein ID: WP_206648341.1
• Coordinates: 1673587..1674078 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q8G4I4
• Locus tag: BLI009_RS07205
• Protein ID: WP_011068030.1
• Coordinates: 1673225..1673587 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI009_RS07200	1670380..1673079	+	2700	WP_206648340.1	aconitate hydratase AcnA	-
BLI009_RS07205	1673225..1673587	+	363	WP_011068030.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BLI009_RS07210	1673587..1674078	+	492	WP_206648341.1	PIN domain-containing protein	Toxin
BLI009_RS07215	1674138..1676243	-	2106	WP_206648342.1	DUF262 domain-containing protein	-
BLI009_RS07220	1676332..1676973	-	642	WP_206648343.1	GNAT family N-acetyltransferase	-
BLI009_RS07225	1677014..1677154	-	141	Protein_1394	response regulator transcription factor	-
BLI009_RS07230	1677438..1678340	+	903	WP_032745207.1	Bax inhibitor-1/YccA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1597845..1715050	117205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18343.93 Da
• Isoelectric Point: 4.6408

>T196007 WP_206648341.1 NZ_CP071248:1673587-1674078 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRSF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDNLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T196007 NZ_CP094998:c474204-473953 [Synechocystis sp. PCC 6803]
ATGAAGTATTTACTAGATACGAATATTTGCATTTATCTCATTAAGAAGAAACCGTTTAAAGTCTTGGCAAAATTTCAAAC
CCTGGAGATATCAGACATTGGTATTTCATCCATTACCGTGGCGGAATTAGAATATGGTGTCAGTAAAAGTCAACAACAAT
CGAAAAATCGTGATGCCTTAATGCAATTCTTGATGCCGCTAGAAATCGTGGAATTTAATTCAGGAAGCGGCGATCGCCTA
TGGCAACATTAG

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 14004.05 Da
• Isoelectric Point: 5.0733

>AT196007 WP_011068030.1 NZ_CP071248:1673225-1673587 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Nucleotide

• Length: 363 bp

>AT196007 NZ_CP094998:c474432-474205 [Synechocystis sp. PCC 6803]
ATGAACACAGCTCAAATTAGCACCGATGGCACCCATCAAATCGTTATTTTACCAGAAAACTTTACGATAGCCGGAAGCGA
AGTTTACATTAAAAAAATTGGAAGTACAATTATTTTGATTGCTAAAAATAACCCTTGGCAATCCTTAATTGAAAGCTTAG
ATCAATTTTCAGATGATTTTATGAAAACTAGGGAACAGCCTCCCTTAGATATACGAGAAGAGTTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S2W1N3