Detailed information of TA system TA196006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1585568..1586151
• Replicon: chromosome
• Accession: NZ_CP071248
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7009

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A1S2VZ23
• Locus tag: BLI009_RS06860
• Protein ID: WP_032745284.1
• Coordinates: 1585849..1586151 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BLI009_RS06855
• Protein ID: WP_206648302.1
• Coordinates: 1585568..1585852 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI009_RS06825	1580960..1581868	+	909	WP_206648297.1	ATP-binding cassette domain-containing protein	-
BLI009_RS06830	1581865..1582596	+	732	WP_206648298.1	ABC transporter permease	-
BLI009_RS06835	1583220..1584248	+	1029	WP_206648299.1	YcaO-like family protein	-
BLI009_RS06840	1584202..1584894	+	693	WP_206648300.1	hypothetical protein	-
BLI009_RS06845	1584969..1585301	-	333	WP_206648301.1	hypothetical protein	-
BLI009_RS06855	1585568..1585852	-	285	WP_206648302.1	putative addiction module antidote protein	Antitoxin
BLI009_RS06860	1585849..1586151	-	303	WP_032745284.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BLI009_RS06865	1586189..1586485	-	297	WP_206649227.1	hypothetical protein	-
BLI009_RS06870	1586644..1587132	+	489	WP_206648303.1	D-tyrosyl-tRNA(Tyr) deacylase	-
BLI009_RS06875	1587293..1590412	+	3120	WP_206648304.1	alpha-mannosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (9-92)

Antitoxin

• Uncharacterized protein HI1420 (5-91)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11350.08 Da
• Isoelectric Point: 10.4626

>T196006 WP_032745284.1 NZ_CP071248:c1586151-1585849 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Nucleotide

• Length: 303 bp

>T196006 NZ_CP094997:c5538904-5538593 [Dyadobacter chenwenxiniae]
ATGATCATACTGGATGCCCACATTCCGCCAAGCCTTGCATTGTGGATTGCCTCTCATTACAACATTGAATGTTATTCTGC
CCGATTTCTAAACTTGTGTGCAGCAGAAGACTGGGAGATATTTACGCTCGCCAAAGAACGAAATGCCATCGTTATTACCA
AAGACGATGATTTTGTCTCACTCCTGAATATACATGGATGCCCGCCAAAGGTTATCTGGCTCACTTGCGGTAACACTTCA
AAAGAAAGACTAAGAGAATTTTGTCTGAAAAACTGCTGCAAGCGCTGGCATTGTTGGAACAAACCGACTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10132.34 Da
• Isoelectric Point: 4.5368

>AT196006 WP_206648302.1 NZ_CP071248:c1585852-1585568 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEHLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Nucleotide

• Length: 285 bp

>AT196006 NZ_CP094997:c5539137-5538904 [Dyadobacter chenwenxiniae]
ATGAATAAGCAACTCCTGGAACGAATCACATTCAATCCGAACCTATGCGGCGGCAAACCTTGTATTCGCAACATGCGTAT
TCGGGTAACTGATGTTATTGAGTTGTTGGCAAACGGGCTGACCGCTGAACAGATCGTAACAGAGGAACTTCCTGATCTTG
AACCGGAGGATATCACCGCCTGCCTGCTATACGCTGCGATTAAATTGAACCATCCCGTTTTGCAAGCTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1S2VZ23