Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 1405431..1405936 Replicon chromosome
Accession NZ_CP071246
Organism Corynebacterium sp. CNCTC7651

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JZY91_RS06810 Protein ID WP_234949082.1
Coordinates 1405431..1405685 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JZY91_RS06815 Protein ID WP_234947127.1
Coordinates 1405685..1405936 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY91_RS06785 (JZY91_06770) 1400519..1402318 - 1800 WP_234947122.1 proline--tRNA ligase -
JZY91_RS06790 (JZY91_06775) 1402350..1403105 + 756 WP_234947123.1 peroxide stress protein YaaA -
JZY91_RS06795 (JZY91_06780) 1403268..1404002 + 735 WP_234947124.1 DUF1648 domain-containing protein -
JZY91_RS06800 (JZY91_06785) 1404007..1404702 + 696 WP_234947125.1 thermonuclease family protein -
JZY91_RS06805 (JZY91_06790) 1404705..1405430 + 726 WP_234947126.1 NAD-dependent deacylase -
JZY91_RS06810 (JZY91_06795) 1405431..1405685 - 255 WP_234949082.1 Txe/YoeB family addiction module toxin Toxin
JZY91_RS06815 (JZY91_06800) 1405685..1405936 - 252 WP_234947127.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JZY91_RS06820 (JZY91_06805) 1406012..1406611 - 600 WP_234947128.1 response regulator transcription factor -
JZY91_RS06825 (JZY91_06810) 1406611..1407729 - 1119 WP_234947129.1 histidine kinase -
JZY91_RS06830 (JZY91_06815) 1407858..1408838 + 981 WP_234947130.1 ABC transporter permease -
JZY91_RS06835 (JZY91_06820) 1408838..1409485 + 648 WP_234947131.1 ABC transporter ATP-binding protein -
JZY91_RS06840 (JZY91_06825) 1409497..1410492 - 996 WP_234947132.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10247.69 Da        Isoelectric Point: 7.3138

>T196003 WP_234949082.1 NZ_CP071246:c1405685-1405431 [Corynebacterium sp. CNCTC7651]
MHLVWDLNAWEDYTYWQNEDRKTLKRINQLLKDMLRDPFEGIGKPEPLKYGAEGAWSRRITQEHRLVYLVEGRDLVILQA
RYHY

Download         Length: 255 bp

>T196003 NZ_CP094994:17676-18092 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9494.55 Da        Isoelectric Point: 4.4915

>AT196003 WP_234947127.1 NZ_CP071246:c1405936-1405685 [Corynebacterium sp. CNCTC7651]
MTMSASEARRTFFPLLEQVNSDREAIEVASRHGNVVIMPADDYAAWVETAYLFRSPANARRLMESYENARAGRFEEHELD
LDA

Download         Length: 252 bp

>AT196003 NZ_CP094994:17449-17679 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References