Detailed information of TA system TA196003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 1405431..1405936
• Replicon: chromosome
• Accession: NZ_CP071246
• Organism: Corynebacterium sp. CNCTC7651

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JZY91_RS06810
• Protein ID: WP_234949082.1
• Coordinates: 1405431..1405685 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JZY91_RS06815
• Protein ID: WP_234947127.1
• Coordinates: 1405685..1405936 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY91_RS06785 (JZY91_06770)	1400519..1402318	-	1800	WP_234947122.1	proline--tRNA ligase	-
JZY91_RS06790 (JZY91_06775)	1402350..1403105	+	756	WP_234947123.1	peroxide stress protein YaaA	-
JZY91_RS06795 (JZY91_06780)	1403268..1404002	+	735	WP_234947124.1	DUF1648 domain-containing protein	-
JZY91_RS06800 (JZY91_06785)	1404007..1404702	+	696	WP_234947125.1	thermonuclease family protein	-
JZY91_RS06805 (JZY91_06790)	1404705..1405430	+	726	WP_234947126.1	NAD-dependent deacylase	-
JZY91_RS06810 (JZY91_06795)	1405431..1405685	-	255	WP_234949082.1	Txe/YoeB family addiction module toxin	Toxin
JZY91_RS06815 (JZY91_06800)	1405685..1405936	-	252	WP_234947127.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JZY91_RS06820 (JZY91_06805)	1406012..1406611	-	600	WP_234947128.1	response regulator transcription factor	-
JZY91_RS06825 (JZY91_06810)	1406611..1407729	-	1119	WP_234947129.1	histidine kinase	-
JZY91_RS06830 (JZY91_06815)	1407858..1408838	+	981	WP_234947130.1	ABC transporter permease	-
JZY91_RS06835 (JZY91_06820)	1408838..1409485	+	648	WP_234947131.1	ABC transporter ATP-binding protein	-
JZY91_RS06840 (JZY91_06825)	1409497..1410492	-	996	WP_234947132.1	methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10247.69 Da
• Isoelectric Point: 7.3138

>T196003 WP_234949082.1 NZ_CP071246:c1405685-1405431 [Corynebacterium sp. CNCTC7651]
MHLVWDLNAWEDYTYWQNEDRKTLKRINQLLKDMLRDPFEGIGKPEPLKYGAEGAWSRRITQEHRLVYLVEGRDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T196003 NZ_CP094994:17676-18092 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9494.55 Da
• Isoelectric Point: 4.4915

>AT196003 WP_234947127.1 NZ_CP071246:c1405936-1405685 [Corynebacterium sp. CNCTC7651]
MTMSASEARRTFFPLLEQVNSDREAIEVASRHGNVVIMPADDYAAWVETAYLFRSPANARRLMESYENARAGRFEEHELD
LDA

Nucleotide

• Length: 252 bp

>AT196003 NZ_CP094994:17449-17679 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA