Detailed information of TA system TA196001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1159880..1160397
• Replicon: chromosome
• Accession: NZ_CP071246
• Organism: Corynebacterium sp. CNCTC7651

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JZY91_RS05585
• Protein ID: WP_234948941.1
• Coordinates: 1160137..1160397 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JZY91_RS05580
• Protein ID: WP_234948940.1
• Coordinates: 1159880..1160143 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY91_RS05550 (JZY91_05535)	1155519..1156097	+	579	WP_234948934.1	TetR/AcrR family transcriptional regulator	-
JZY91_RS05555 (JZY91_05540)	1156108..1156842	+	735	WP_234948935.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
JZY91_RS05560 (JZY91_05545)	1156909..1157583	-	675	WP_234948936.1	NAD(P)H-binding protein	-
JZY91_RS05565 (JZY91_05550)	1157603..1158106	-	504	WP_234948937.1	hypothetical protein	-
JZY91_RS05570 (JZY91_05555)	1158144..1158425	+	282	WP_234948938.1	ACT domain-containing protein	-
JZY91_RS05575 (JZY91_05560)	1158438..1159808	+	1371	WP_234948939.1	PFL family protein	-
JZY91_RS05580 (JZY91_05565)	1159880..1160143	+	264	WP_234948940.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JZY91_RS05585 (JZY91_05570)	1160137..1160397	+	261	WP_234948941.1	Txe/YoeB family addiction module toxin	Toxin
JZY91_RS05590 (JZY91_05575)	1160404..1160649	-	246	WP_234948942.1	PLDc N-terminal domain-containing protein	-
JZY91_RS05595 (JZY91_05580)	1160706..1161443	+	738	WP_234948943.1	glutamine amidotransferase	-
JZY91_RS05600 (JZY91_05585)	1161586..1162599	+	1014	WP_234948944.1	hypothetical protein	-
JZY91_RS05605 (JZY91_05590)	1162596..1163144	-	549	WP_234948945.1	DUF421 domain-containing protein	-
JZY91_RS05610 (JZY91_05595)	1163144..1164772	-	1629	WP_234948946.1	ABC-F family ATP-binding cassette domain-containing protein	-
JZY91_RS05615 (JZY91_05600)	1164806..1165225	-	420	WP_234948947.1	metal-sulfur cluster assembly factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10359.75 Da
• Isoelectric Point: 8.4870

>T196001 WP_234948941.1 NZ_CP071246:1160137-1160397 [Corynebacterium sp. CNCTC7651]
VLVRWERDAWEEYCRRQIEDRRILKRINTLITDVLRNGNEGIGKPEPLKHDFSGYWSRRINSEHRLIYKIDDGGITIVAC
RYHYGE

Nucleotide

• Length: 261 bp

>T196001 NZ_CP094992:c282088-281645 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9901.21 Da
• Isoelectric Point: 4.4755

>AT196001 WP_234948940.1 NZ_CP071246:1159880-1160143 [Corynebacterium sp. CNCTC7651]
VRIMSYTESRAKYADMLTSVVDDCEEVIITRAGHEPVVVVSLAEYESLKETAYLLRSPANARMLKERIARVERGQAEEHE
LIEDDTC

Nucleotide

• Length: 264 bp

>AT196001 NZ_CP094992:c282315-282085 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA