Detailed information of TA system TA196000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1026466..1027124
• Replicon: chromosome
• Accession: NZ_CP071246
• Organism: Corynebacterium sp. CNCTC7651

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JZY91_RS04950
• Protein ID: WP_234948834.1
• Coordinates: 1026466..1026894 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JZY91_RS04955
• Protein ID: WP_234948835.1
• Coordinates: 1026891..1027124 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY91_RS04930 (JZY91_04910)	1022045..1024900	+	2856	WP_234948831.1	excinuclease ABC subunit UvrA	-
JZY91_RS04935 (JZY91_04915)	1025212..1025733	+	522	WP_095659887.1	translation initiation factor IF-3	-
JZY91_RS04940 (JZY91_04920)	1025762..1025956	+	195	WP_234948832.1	50S ribosomal protein L35	-
JZY91_RS04945 (JZY91_04925)	1026005..1026391	+	387	WP_234948833.1	50S ribosomal protein L20	-
JZY91_RS04950 (JZY91_04930)	1026466..1026894	-	429	WP_234948834.1	type II toxin-antitoxin system VapC family toxin	Toxin
JZY91_RS04955 (JZY91_04935)	1026891..1027124	-	234	WP_234948835.1	toxin-antitoxin system	Antitoxin
JZY91_RS04960 (JZY91_04940)	1027216..1028034	+	819	WP_234948836.1	RNA methyltransferase	-
JZY91_RS04965 (JZY91_04945)	1027969..1028667	-	699	WP_234948837.1	hypothetical protein	-
JZY91_RS04970 (JZY91_04950)	1028686..1029099	-	414	WP_234948838.1	type II toxin-antitoxin system VapC family toxin	-
JZY91_RS04975 (JZY91_04955)	1029096..1029329	-	234	WP_234948839.1	toxin-antitoxin system	-
JZY91_RS04980 (JZY91_04960)	1029571..1030620	+	1050	WP_234948840.1	phenylalanine--tRNA ligase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-131)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16078.38 Da
• Isoelectric Point: 5.2301

>T196000 WP_234948834.1 NZ_CP071246:c1026894-1026466 [Corynebacterium sp. CNCTC7651]
VIIWDTNVVSEFLKSDPDPRVRVSIERSMRDTPGLAALCTMTLGEIWQGIAYLKPGRRRTALEQSFTTWLELMPPEHVLP
FGAEEARIFGDVRAHRKAIGRPISYPDAIIAATCIAHDATLFTRNTSDFDELNLRLVNPWED

Nucleotide

• Length: 429 bp

>T196000 NZ_CP094992:149339-149809 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8760.95 Da
• Isoelectric Point: 4.8668

>AT196000 WP_234948835.1 NZ_CP071246:c1027124-1026891 [Corynebacterium sp. CNCTC7651]
MASLIVRNLDERVKEALAERARLQGRSMEAEVRDILHRAVAPTNPLEELHQLVSRADASVDLELPDRVIDERKVDFS

Nucleotide

• Length: 234 bp

>AT196000 NZ_CP094992:148899-149342 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCCAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA