Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD-PIN
Location 365866..366535 Replicon chromosome
Accession NZ_CP071246
Organism Corynebacterium sp. CNCTC7651

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JZY91_RS01810 Protein ID WP_234948293.1
Coordinates 365866..366282 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JZY91_RS01815 Protein ID WP_234948294.1
Coordinates 366266..366535 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY91_RS01805 (JZY91_01800) 365522..365869 + 348 Protein_348 exodeoxyribonuclease III -
JZY91_RS01810 (JZY91_01805) 365866..366282 - 417 WP_234948293.1 type II toxin-antitoxin system VapC family toxin Toxin
JZY91_RS01815 (JZY91_01810) 366266..366535 - 270 WP_234948294.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JZY91_RS01820 (JZY91_01815) 366618..367010 - 393 WP_234948295.1 type II toxin-antitoxin system VapC family toxin -
JZY91_RS01825 (JZY91_01820) 367370..368440 + 1071 WP_234948296.1 biotin synthase BioB -
JZY91_RS01830 (JZY91_01825) 368440..368643 + 204 WP_234948297.1 hypothetical protein -
JZY91_RS01835 (JZY91_01830) 368662..369006 - 345 WP_234949012.1 type II toxin-antitoxin system PemK/MazF family toxin -
JZY91_RS01840 (JZY91_01835) 369292..369978 - 687 WP_234948298.1 hypothetical protein -
JZY91_RS01845 (JZY91_01840) 369975..370664 - 690 WP_234948299.1 ATP-binding cassette domain-containing protein -
JZY91_RS01850 (JZY91_01845) 370661..371014 - 354 WP_234948300.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 335364..380773 45409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-126)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-46)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14837.77 Da        Isoelectric Point: 4.5562

>T195998 WP_234948293.1 NZ_CP071246:c366282-365866 [Corynebacterium sp. CNCTC7651]
VTSVFEPVHRWYLDTSAALKFFADEAESDALEQAILESSPQIFSSTLLETELRRVAVRHPEIAQSEISDFLQSIELVTLT
QAAFRLAGQLPGATLRSLDALHLTAALLGGASAIVTYDRRLQEAAKSAGLTALAPGQS

Download         Length: 417 bp

>T195998 NZ_CP094991:c5272784-5272401 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10203.70 Da        Isoelectric Point: 10.2120

>AT195998 WP_234948294.1 NZ_CP071246:c366535-366266 [Corynebacterium sp. CNCTC7651]
MTMAEHISQRELRNDSGKILRAVEAGEEFVITNRGRPVARLVGVEDGAERRCILPVQKPSRPLRIGKQYRRKLSATTDEL
LEGYRDERI

Download         Length: 270 bp

>AT195998 NZ_CP094991:c5273026-5272784 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References