Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 335119..335768 Replicon chromosome
Accession NZ_CP071246
Organism Corynebacterium sp. CNCTC7651

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JZY91_RS01700 Protein ID WP_234948272.1
Coordinates 335364..335768 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JZY91_RS01695 Protein ID WP_234948271.1
Coordinates 335119..335358 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY91_RS01680 (JZY91_01675) 332593..333045 + 453 WP_234948268.1 PH domain-containing protein -
JZY91_RS01685 (JZY91_01680) 333042..334388 + 1347 WP_234948269.1 PH domain-containing protein -
JZY91_RS01690 (JZY91_01685) 334393..335043 + 651 WP_234948270.1 MOSC domain-containing protein -
JZY91_RS01695 (JZY91_01690) 335119..335358 + 240 WP_234948271.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JZY91_RS01700 (JZY91_01695) 335364..335768 + 405 WP_234948272.1 type II toxin-antitoxin system VapC family toxin Toxin
JZY91_RS01705 (JZY91_01700) 335765..336232 - 468 WP_234948273.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
JZY91_RS01710 (JZY91_01705) 336236..337591 - 1356 WP_234948274.1 amidohydrolase -
JZY91_RS01715 (JZY91_01710) 337644..338522 + 879 WP_234948275.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JZY91_RS01720 (JZY91_01715) 338524..338868 + 345 WP_234948276.1 DUF3017 domain-containing protein -
JZY91_RS01725 (JZY91_01720) 338969..339628 + 660 WP_234948277.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin

SpoVT-AbrB domain

(3-42)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14347.43 Da        Isoelectric Point: 6.4793

>T195997 WP_234948272.1 NZ_CP071246:335364-335768 [Corynebacterium sp. CNCTC7651]
VIALDTSLAVPLLLGTHNAHESVKRWAKGRELTLCAHSLVETYSVLTRLPGDNRLAGSDAVQVIDDNFPKPLMLPDTVGE
DIHRRLAKAGVLGGATYDGIVALTALENGVPLASRDRRAVNNYLSLGVEVQLVN

Download         Length: 405 bp

>T195997 NZ_CP094991:c4955243-4954326 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8145.28 Da        Isoelectric Point: 4.9423

>AT195997 WP_234948271.1 NZ_CP071246:335119-335358 [Corynebacterium sp. CNCTC7651]
MQAKIDAGGRLLLPKALRDALGLTPGSVVDISAYGGGLTVIPGGRTARVERNEDGFLVAYGSTEVTDADVFALIDAGRK

Download         Length: 240 bp

>AT195997 NZ_CP094991:c4956007-4955249 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References