Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3786321..3786977 Replicon chromosome
Accession NZ_CP071244
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S37_jyu2015

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YUY4
Locus tag J0F95_RS18105 Protein ID WP_033639649.1
Coordinates 3786321..3786710 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YUX3
Locus tag J0F95_RS18110 Protein ID WP_033639648.1
Coordinates 3786714..3786977 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F95_RS18090 3782789..3784219 + 1431 WP_033639650.1 multidrug transporter subunit MdtD -
J0F95_RS18095 3784216..3785598 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
J0F95_RS18100 3785598..3786314 + 717 WP_004941568.1 two-component system response regulator BaeR -
J0F95_RS18105 3786321..3786710 - 390 WP_033639649.1 type II toxin-antitoxin system VapC family toxin Toxin
J0F95_RS18110 3786714..3786977 - 264 WP_033639648.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J0F95_RS18115 3787316..3787654 + 339 WP_016926703.1 YegP family protein -
J0F95_RS18120 3787833..3789185 + 1353 WP_028127781.1 tRNA 5-hydroxyuridine modification protein YegQ -
J0F95_RS18125 3789653..3790558 + 906 WP_016926701.1 lipid kinase YegS -
J0F95_RS18130 3790727..3791941 + 1215 WP_033639647.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 7.8794

>T195993 WP_033639649.1 NZ_CP071244:c3786710-3786321 [Serratia marcescens subsp. marcescens ATCC 13880]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAIDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T195993 NZ_CP094991:4052281-4052499 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10094.37 Da        Isoelectric Point: 4.6702

>AT195993 WP_033639648.1 NZ_CP071244:c3786977-3786714 [Serratia marcescens subsp. marcescens ATCC 13880]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGMADR
DPFSEEE

Download         Length: 264 bp

>AT195993 NZ_CP094991:4051880-4052254 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YUY4

Antitoxin

Source ID Structure
AlphaFold DB A0A379YUX3

References