Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4455249..4455844 Replicon chromosome
Accession NZ_CP071242
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S55_jyu2015

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S6LRI1
Locus tag J0F96_RS21260 Protein ID WP_071605322.1
Coordinates 4455590..4455844 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J0F96_RS21255 Protein ID WP_033633573.1
Coordinates 4455249..4455590 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F96_RS21235 4450757..4451572 - 816 WP_033639337.1 GPO family capsid scaffolding protein -
J0F96_RS21240 4451715..4453487 + 1773 WP_033639336.1 terminase ATPase subunit family protein -
J0F96_RS21245 4453487..4454173 + 687 WP_060445964.1 terminase family protein -
J0F96_RS21250 4454170..4455204 + 1035 WP_033639335.1 phage portal protein -
J0F96_RS21255 4455249..4455590 - 342 WP_033633573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J0F96_RS21260 4455590..4455844 - 255 WP_071605322.1 type II toxin-antitoxin system HicA family toxin Toxin
J0F96_RS21265 4456214..4456411 - 198 WP_126186641.1 hypothetical protein -
J0F96_RS21270 4456459..4456683 - 225 WP_033639333.1 hypothetical protein -
J0F96_RS21275 4456722..4458938 - 2217 WP_033639332.1 replication endonuclease -
J0F96_RS21280 4458935..4459249 - 315 WP_033639331.1 DUF3850 domain-containing protein -
J0F96_RS21285 4459263..4459436 - 174 WP_162531492.1 hypothetical protein -
J0F96_RS21290 4459376..4459600 - 225 WP_033639330.1 TraR/DksA C4-type zinc finger protein -
J0F96_RS21295 4459600..4459842 - 243 WP_023447523.1 DUF2732 family protein -
J0F96_RS21300 4459906..4460208 - 303 WP_031221632.1 hypothetical protein -
J0F96_RS21305 4460220..4460399 - 180 WP_072009648.1 DUF2724 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4426655..4463437 36782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9495.97 Da        Isoelectric Point: 11.1073

>T195979 WP_071605322.1 NZ_CP071242:c4455844-4455590 [Serratia marcescens subsp. marcescens ATCC 13880]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

>T195979 NZ_CP094987:c4429211-4429104 [Shigella flexneri]
ATGACGTTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12399.90 Da        Isoelectric Point: 4.5789

>AT195979 WP_033633573.1 NZ_CP071242:c4455590-4455249 [Serratia marcescens subsp. marcescens ATCC 13880]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 342 bp

>AT195979 NZ_CP094987:4429269-4429323 [Shigella flexneri]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S6LRI1

Antitoxin

Source ID Structure

References