Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4164015..4164684 Replicon chromosome
Accession NZ_CP071240
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S64_jyu2015

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag J0G05_RS19890 Protein ID WP_016929976.1
Coordinates 4164015..4164437 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag J0G05_RS19895 Protein ID WP_004931679.1
Coordinates 4164418..4164684 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G05_RS19870 4159901..4160419 + 519 WP_033639477.1 flavodoxin FldB -
J0G05_RS19875 4160457..4161821 - 1365 WP_033639476.1 cell envelope integrity protein CreD -
J0G05_RS19880 4161902..4163320 - 1419 WP_033639474.1 two-component system sensor histidine kinase CreC -
J0G05_RS19885 4163317..4164015 - 699 WP_033639472.1 two-component system response regulator CreB -
J0G05_RS19890 4164015..4164437 - 423 WP_016929976.1 protein YgfX Toxin
J0G05_RS19895 4164418..4164684 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
J0G05_RS19900 4165005..4165997 + 993 WP_033639470.1 tRNA-modifying protein YgfZ -
J0G05_RS19905 4166036..4166533 - 498 WP_033639468.1 DUF2165 domain-containing protein -
J0G05_RS19910 4166684..4167358 - 675 WP_033639467.1 hemolysin III family protein -
J0G05_RS19915 4167542..4168150 + 609 WP_028127691.1 HD domain-containing protein -
J0G05_RS19920 4168191..4169117 - 927 WP_033639466.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T195962 WP_016929976.1 NZ_CP071240:c4164437-4164015 [Serratia marcescens subsp. marcescens ATCC 13880]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T195962 NZ_CP094975:c5385690-5385508 [Pseudomonas sp. PIA16]
GTGCAGAGCAGACAACTGATCAAGGAGCTTGAAATGGCAGGGTGGGTATTGAAACGGGTCACTGGCAGCCATCACATTTT
CAAGCACCCTTGGCACAGAGCCTCACTCCCGGCACCACACCCCAAAAAGGACTTACCCTTGGGCACGGTGAAAAGCATCA
AGGCCCGGGCGGGTTTGCTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT195962 WP_004931679.1 NZ_CP071240:c4164684-4164418 [Serratia marcescens subsp. marcescens ATCC 13880]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT195962 NZ_CP094975:c5385478-5385074 [Pseudomonas sp. PIA16]
ATGCAATATCCCATCTGTATCGAATGGGGCGACGAAGGTACCGCCATCGGTATCCAGATCCCCGACATTCCTGGCGCCGT
CACCGCCGGCGATACCTTCGAAGATGCCTACAATGCGGCCATCGAAGTGGCGCACATCATGCTCGAAGAGATCGTCGCCG
ACACCGGCGAAGTGCCCATGCCCACCTCGGCTGCCCAGCATCGCAGCCACCCGGACCTGGCCAACATGGGCTGGGGCATG
CTGGAGATCGACATTACGCCGTACCTGGGTAAAACCGAGAAGGTCAACGTGACCTTGCCCGGTTTCGTGGTCAAGCGTAT
CGACCGTTTCGTGCGTGACCACAGCGTCAAGAGCCGCTCCTCGTTCCTGGCCGATGCGGCACTTGAGAAGCTGGGCAGGG
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References