Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1109089..1109710 Replicon chromosome
Accession NZ_CP071234
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S95_jyu2015

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag J0G04_RS05175 Protein ID WP_004940313.1
Coordinates 1109089..1109292 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag J0G04_RS05180 Protein ID WP_004940312.1
Coordinates 1109342..1109710 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G04_RS05145 1104789..1105127 + 339 WP_004940327.1 P-II family nitrogen regulator -
J0G04_RS05150 1105163..1106449 + 1287 WP_004940322.1 ammonium transporter AmtB -
J0G04_RS05155 1106540..1107403 - 864 WP_016928847.1 acyl-CoA thioesterase II -
J0G04_RS05160 1107634..1108125 + 492 WP_016928846.1 YbaY family lipoprotein -
J0G04_RS05165 1108190..1108504 - 315 WP_004940317.1 MGMT family protein -
J0G04_RS05175 1109089..1109292 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
J0G04_RS05180 1109342..1109710 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
J0G04_RS05185 1109869..1110222 - 354 WP_016928845.1 hypothetical protein -
J0G04_RS05190 1110627..1111340 + 714 WP_033641138.1 ABC transporter ATP-binding protein -
J0G04_RS05195 1111337..1112194 + 858 WP_004940309.1 metal ABC transporter permease -
J0G04_RS05200 1112220..1113098 + 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
J0G04_RS05205 1113206..1113346 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
J0G04_RS05210 1113359..1113613 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T195902 WP_004940313.1 NZ_CP071234:c1109292-1109089 [Serratia marcescens subsp. marcescens ATCC 13880]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T195902 NZ_CP094926:c1145108-1144899 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT195902 WP_004940312.1 NZ_CP071234:c1109710-1109342 [Serratia marcescens subsp. marcescens ATCC 13880]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT195902 NZ_CP094926:c1145413-1145120 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References