Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1601563..1602110 Replicon chromosome
Accession NZ_CP071228
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S78_jyu2015

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag J0F98_RS07645 Protein ID WP_025302144.1
Coordinates 1601802..1602110 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag J0F98_RS07640 Protein ID WP_033633717.1
Coordinates 1601563..1601799 (+) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F98_RS07625 1598049..1599584 + 1536 WP_033640885.1 glutathione ABC transporter substrate-binding protein GsiB -
J0F98_RS07630 1599637..1600557 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
J0F98_RS07635 1600567..1601475 + 909 WP_181817231.1 glutathione ABC transporter permease GsiD -
J0F98_RS07640 1601563..1601799 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J0F98_RS07645 1601802..1602110 + 309 WP_025302144.1 CcdB family protein Toxin
J0F98_RS07650 1602147..1602989 - 843 WP_015377214.1 S-formylglutathione hydrolase -
J0F98_RS07655 1603004..1604128 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
J0F98_RS07660 1604158..1605078 - 921 WP_033640884.1 LysR family transcriptional regulator -
J0F98_RS07665 1605184..1606341 + 1158 WP_033640883.1 YbfB/YjiJ family MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-101)

Antitoxin

(8-78)


Sequences


Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T195855 WP_025302144.1 NZ_CP071228:1601802-1602110 [Serratia marcescens subsp. marcescens ATCC 13880]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T195855 NZ_CP094857:c2101772-2101563 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT195855 WP_033633717.1 NZ_CP071228:1601563-1601799 [Serratia marcescens subsp. marcescens ATCC 13880]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT195855 NZ_CP094857:c2102077-2101784 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A380ADA6


Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References