Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1107833..1108454 Replicon chromosome
Accession NZ_CP071228
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S78_jyu2015

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag J0F98_RS05170 Protein ID WP_004940313.1
Coordinates 1107833..1108036 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag J0F98_RS05175 Protein ID WP_004940312.1
Coordinates 1108086..1108454 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F98_RS05140 1103533..1103871 + 339 WP_004940327.1 P-II family nitrogen regulator -
J0F98_RS05145 1103907..1105193 + 1287 WP_004940322.1 ammonium transporter AmtB -
J0F98_RS05150 1105284..1106147 - 864 WP_016928847.1 acyl-CoA thioesterase II -
J0F98_RS05155 1106378..1106869 + 492 WP_016928846.1 YbaY family lipoprotein -
J0F98_RS05160 1106934..1107248 - 315 WP_004940317.1 MGMT family protein -
J0F98_RS05170 1107833..1108036 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
J0F98_RS05175 1108086..1108454 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
J0F98_RS05180 1108613..1108966 - 354 WP_016928845.1 hypothetical protein -
J0F98_RS05185 1109371..1110084 + 714 WP_033641138.1 ABC transporter ATP-binding protein -
J0F98_RS05190 1110081..1110938 + 858 WP_004940309.1 metal ABC transporter permease -
J0F98_RS05195 1110964..1111842 + 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
J0F98_RS05200 1111950..1112090 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
J0F98_RS05205 1112103..1112357 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T195854 WP_004940313.1 NZ_CP071228:c1108036-1107833 [Serratia marcescens subsp. marcescens ATCC 13880]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T195854 NZ_CP094857:c2082186-2081824 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT195854 WP_004940312.1 NZ_CP071228:c1108454-1108086 [Serratia marcescens subsp. marcescens ATCC 13880]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT195854 NZ_CP094857:c2082353-2082183 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References