Detailed information of TA system TA195851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4454012..4454607
• Replicon: chromosome
• Accession: NZ_CP071226
• Organism: Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S22_jyu2015

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: J0G07_RS21250
• Protein ID: WP_071605322.1
• Coordinates: 4454353..4454607 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: J0G07_RS21245
• Protein ID: WP_033633573.1
• Coordinates: 4454012..4454353 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0G07_RS21225	4449520..4450335	-	816	WP_033639337.1	GPO family capsid scaffolding protein	-
J0G07_RS21230	4450478..4452250	+	1773	WP_033639336.1	terminase ATPase subunit family protein	-
J0G07_RS21235	4452250..4452936	+	687	WP_060445964.1	terminase family protein	-
J0G07_RS21240	4452933..4453967	+	1035	WP_033639335.1	phage portal protein	-
J0G07_RS21245	4454012..4454353	-	342	WP_033633573.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J0G07_RS21250	4454353..4454607	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
J0G07_RS21255	4454977..4455174	-	198	WP_126186641.1	hypothetical protein	-
J0G07_RS21260	4455222..4455446	-	225	WP_033639333.1	hypothetical protein	-
J0G07_RS21265	4455485..4457701	-	2217	WP_033639332.1	replication endonuclease	-
J0G07_RS21270	4457698..4458012	-	315	WP_033639331.1	DUF3850 domain-containing protein	-
J0G07_RS21275	4458026..4458199	-	174	WP_162531492.1	hypothetical protein	-
J0G07_RS21280	4458139..4458363	-	225	WP_033639330.1	TraR/DksA C4-type zinc finger protein	-
J0G07_RS21285	4458363..4458605	-	243	WP_023447523.1	DUF2732 family protein	-
J0G07_RS21290	4458669..4458971	-	303	WP_031221632.1	hypothetical protein	-
J0G07_RS21295	4458983..4459162	-	180	WP_072009648.1	DUF2724 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	rfaE	4413300..4462200	48900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T195851 WP_071605322.1 NZ_CP071226:c4454607-4454353 [Serratia marcescens subsp. marcescens ATCC 13880]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T195851 NZ_CP094857:c1884850-1884698 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12399.90 Da
• Isoelectric Point: 4.5789

>AT195851 WP_033633573.1 NZ_CP071226:c4454353-4454012 [Serratia marcescens subsp. marcescens ATCC 13880]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT195851 NZ_CP094857:c1885474-1884875 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1