Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 4453992..4454587 | Replicon | chromosome |
| Accession | NZ_CP071220 | ||
| Organism | Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S57_jyu2015 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1S6LRI1 |
| Locus tag | J0F88_RS21250 | Protein ID | WP_071605322.1 |
| Coordinates | 4454333..4454587 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | J0F88_RS21245 | Protein ID | WP_033633573.1 |
| Coordinates | 4453992..4454333 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J0F88_RS21225 | 4449500..4450315 | - | 816 | WP_033639337.1 | GPO family capsid scaffolding protein | - |
| J0F88_RS21230 | 4450458..4452230 | + | 1773 | WP_033639336.1 | terminase ATPase subunit family protein | - |
| J0F88_RS21235 | 4452230..4452916 | + | 687 | WP_060445964.1 | terminase family protein | - |
| J0F88_RS21240 | 4452913..4453947 | + | 1035 | WP_033639335.1 | phage portal protein | - |
| J0F88_RS21245 | 4453992..4454333 | - | 342 | WP_033633573.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J0F88_RS21250 | 4454333..4454587 | - | 255 | WP_071605322.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J0F88_RS21255 | 4454957..4455154 | - | 198 | WP_126186641.1 | hypothetical protein | - |
| J0F88_RS21260 | 4455202..4455426 | - | 225 | WP_033639333.1 | hypothetical protein | - |
| J0F88_RS21265 | 4455465..4457681 | - | 2217 | WP_033639332.1 | replication endonuclease | - |
| J0F88_RS21270 | 4457678..4457992 | - | 315 | WP_033639331.1 | DUF3850 domain-containing protein | - |
| J0F88_RS21275 | 4458006..4458179 | - | 174 | WP_162531492.1 | hypothetical protein | - |
| J0F88_RS21280 | 4458119..4458343 | - | 225 | WP_033639330.1 | TraR/DksA C4-type zinc finger protein | - |
| J0F88_RS21285 | 4458343..4458585 | - | 243 | WP_023447523.1 | DUF2732 family protein | - |
| J0F88_RS21290 | 4458649..4458951 | - | 303 | WP_031221632.1 | hypothetical protein | - |
| J0F88_RS21295 | 4458963..4459142 | - | 180 | WP_072009648.1 | DUF2724 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | rfaE | 4413280..4462180 | 48900 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9495.97 Da Isoelectric Point: 11.1073
>T195803 WP_071605322.1 NZ_CP071220:c4454587-4454333 [Serratia marcescens subsp. marcescens ATCC 13880]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP
Download Length: 255 bp
>T195803 NZ_CP094824:2371938-2372402 [Mammaliicoccus sciuri]
ATGGGATTATACGAAGAAACTTTAATACAACATGACTATATAGAAGTAAGAGAGGCGAATGTACTTCCTGATGATTTAGA
TGGAGTCTGGCTAGGTGATCTAATATTAATTAAACGTAACCTACCAGAAAAGAAGAAAGTCGAAGTCCTTTTTGAAGAAT
TAGCACATCACAAACTTACATACGGTGACATCACCAATCAAAAACAGTTCAATAACCGAAAATTCGAAAATTACGCTAGA
CGCTATTCATACGAAAAGTCTATGCCCCTATCGGGTATAGTCCAGGCGTTTGAGCAAGGGGTACATAATCTGTACGAGCT
TGCTAATTTTTTTGAGATTTCAGAAGGTCACGTACTAGATTGTATTGAGCATTATAAAGCTAAGTATGGTTTGTCCACCT
ATCACAAGGGTTATGTCATTAAATTTGACCCTTTGCAGGTGTTTAAACATATAGAATTTGAATAA
ATGGGATTATACGAAGAAACTTTAATACAACATGACTATATAGAAGTAAGAGAGGCGAATGTACTTCCTGATGATTTAGA
TGGAGTCTGGCTAGGTGATCTAATATTAATTAAACGTAACCTACCAGAAAAGAAGAAAGTCGAAGTCCTTTTTGAAGAAT
TAGCACATCACAAACTTACATACGGTGACATCACCAATCAAAAACAGTTCAATAACCGAAAATTCGAAAATTACGCTAGA
CGCTATTCATACGAAAAGTCTATGCCCCTATCGGGTATAGTCCAGGCGTTTGAGCAAGGGGTACATAATCTGTACGAGCT
TGCTAATTTTTTTGAGATTTCAGAAGGTCACGTACTAGATTGTATTGAGCATTATAAAGCTAAGTATGGTTTGTCCACCT
ATCACAAGGGTTATGTCATTAAATTTGACCCTTTGCAGGTGTTTAAACATATAGAATTTGAATAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12399.90 Da Isoelectric Point: 4.5789
>AT195803 WP_033633573.1 NZ_CP071220:c4454333-4453992 [Serratia marcescens subsp. marcescens ATCC 13880]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS
Download Length: 342 bp
>AT195803 NZ_CP094824:2371611-2371925 [Mammaliicoccus sciuri]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCTGAATTGGGTAGAAAAATTGGCAA
AACTGAAGCTACCGTTCAACGATATGAAAGCGGCAATATTAAAAATTTAAAAAACGACACTATAGAAAGTATTGCCGAAG
CATTGAATGTAAATCCTGCCTATTTAATGGGGTGGATTGATGAAGACAATGATGAAGTACAACATCGTGCAGCTCACTTA
GAAGGTAACCTAACTGATGATGAGTGGAAACGCGTGTTAGATTATGCAGATTATATTAGAAGTAGACGCAAATAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCTGAATTGGGTAGAAAAATTGGCAA
AACTGAAGCTACCGTTCAACGATATGAAAGCGGCAATATTAAAAATTTAAAAAACGACACTATAGAAAGTATTGCCGAAG
CATTGAATGTAAATCCTGCCTATTTAATGGGGTGGATTGATGAAGACAATGATGAAGTACAACATCGTGCAGCTCACTTA
GAAGGTAACCTAACTGATGATGAGTGGAAACGCGTGTTAGATTATGCAGATTATATTAGAAGTAGACGCAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|