Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1602818..1603365 Replicon chromosome
Accession NZ_CP071216
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S24_jyu2015

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag J0G01_RS07655 Protein ID WP_025302144.1
Coordinates 1603057..1603365 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag J0G01_RS07650 Protein ID WP_033633717.1
Coordinates 1602818..1603054 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G01_RS07635 1599304..1600839 + 1536 WP_033640885.1 glutathione ABC transporter substrate-binding protein GsiB -
J0G01_RS07640 1600892..1601812 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
J0G01_RS07645 1601822..1602730 + 909 WP_181817231.1 glutathione ABC transporter permease GsiD -
J0G01_RS07650 1602818..1603054 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J0G01_RS07655 1603057..1603365 + 309 WP_025302144.1 CcdB family protein Toxin
J0G01_RS07660 1603402..1604244 - 843 WP_015377214.1 S-formylglutathione hydrolase -
J0G01_RS07665 1604259..1605383 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
J0G01_RS07670 1605413..1606333 - 921 WP_033640884.1 LysR family transcriptional regulator -
J0G01_RS07675 1606439..1607596 + 1158 WP_033640883.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T195759 WP_025302144.1 NZ_CP071216:1603057-1603365 [Serratia marcescens subsp. marcescens ATCC 13880]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T195759 NZ_CP094809:981890-982045 [Staphylococcus agnetis]
ATGTCTGATGAAAAGCATATTGAACATGAAAATGAAATGGTAGATAATTTTGAAGATCTCGTTCAATTAGGTAAAGAAAT
GGAACAGATTTCTGAGACAAATGATCAAGATAAAGTCAATCAATCACATGACCCGGATATTCGTTCAGATCAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT195759 WP_033633717.1 NZ_CP071216:1602818-1603054 [Serratia marcescens subsp. marcescens ATCC 13880]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT195759 NZ_CP094809:981272-981871 [Staphylococcus agnetis]
ATGGCAATGAACTTTAAAGTATTTAAAGACAAAGATACTGTAGCGGTTTATGCGGCAGATATCATTCGAAAACAATTTAA
TAATAATCCAACCACGATAGCAGGATTTCATCTTAGTGAAGAGGAAGCGCCTGTCTTAGACTATTTAAAACGTAATGTTA
ACGACCATGCGGTTGATTTTAGTCAAATTCACATTTTAGATTATGATAAACAAGCGTCATATTTTAAGGCGCTTGGTATC
CCTGAAAAACAAATTCATGAAATCCCTGAAGAAGACGAAGTAGAAAAATTCATTGAACATAAAGCGAAAACAAAAGACAA
TAAAGGTAAACTTACATTACAAGTAGTGTCTATTAATAATAAAGGGGAATTTGGTGTCCCTGTTAATAATGGCTTAAAAC
CAGCACGTGAGATTTTTGTTGTTGTGACTGGAAGCGATAAAGCGGATGTGATTAAAAAATTATATGAGGATAATGGTAAT
ACGAGCTTTATTCCTTCTAGTTTGAAAACACACCGTATGGTGAATGTGATTCTTGATGAAGCTGCAGCTCAAGGATTACC
GGATGACGTAAGAGAATATTTCACTTCTCTTTATGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380ADA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References