Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3109108..3109739 Replicon chromosome
Accession NZ_CP071212
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S50_jyu2015

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag J0G06_RS14875 Protein ID WP_033640020.1
Coordinates 3109108..3109506 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J0G06_RS14880 Protein ID WP_033640019.1
Coordinates 3109506..3109739 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G06_RS14850 3104683..3105057 + 375 WP_033640023.1 type II toxin-antitoxin system RelE/ParE family toxin -
J0G06_RS14855 3105050..3105352 + 303 WP_015378258.1 DNA-binding transcriptional regulator -
J0G06_RS14860 3105355..3105759 - 405 WP_033640022.1 flagellar protein FlhE -
J0G06_RS14865 3105759..3107837 - 2079 WP_016927291.1 flagellar biosynthesis protein FlhA -
J0G06_RS14870 3107830..3108981 - 1152 WP_033640021.1 flagellar type III secretion system protein FlhB -
J0G06_RS14875 3109108..3109506 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
J0G06_RS14880 3109506..3109739 - 234 WP_033640019.1 antitoxin Antitoxin
J0G06_RS14885 3109889..3110533 - 645 WP_004934858.1 protein phosphatase CheZ -
J0G06_RS14890 3110544..3110933 - 390 WP_004934862.1 chemotaxis response regulator CheY -
J0G06_RS14895 3111036..3112085 - 1050 WP_033640018.1 chemotaxis response regulator protein-glutamate methylesterase -
J0G06_RS14900 3112085..3112957 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
J0G06_RS14905 3112995..3114611 - 1617 WP_033640017.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T195736 WP_033640020.1 NZ_CP071212:c3109506-3109108 [Serratia marcescens subsp. marcescens ATCC 13880]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T195736 NZ_CP094800:1873123-1873218 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8799.82 Da        Isoelectric Point: 5.0789

>AT195736 WP_033640019.1 NZ_CP071212:c3109739-3109506 [Serratia marcescens subsp. marcescens ATCC 13880]
MTLGSVFTNNRTQAVRLPAEARFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREAF

Download         Length: 234 bp

>AT195736 NZ_CP094800:c1873303-1873246 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure

References