Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1107831..1108452 Replicon chromosome
Accession NZ_CP071210
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S89_jyu2015

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag J0F93_RS05170 Protein ID WP_004940313.1
Coordinates 1107831..1108034 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag J0F93_RS05175 Protein ID WP_004940312.1
Coordinates 1108084..1108452 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F93_RS05140 1103531..1103869 + 339 WP_004940327.1 P-II family nitrogen regulator -
J0F93_RS05145 1103905..1105191 + 1287 WP_004940322.1 ammonium transporter AmtB -
J0F93_RS05150 1105282..1106145 - 864 WP_016928847.1 acyl-CoA thioesterase II -
J0F93_RS05155 1106376..1106867 + 492 WP_016928846.1 YbaY family lipoprotein -
J0F93_RS05160 1106932..1107246 - 315 WP_004940317.1 MGMT family protein -
J0F93_RS05170 1107831..1108034 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
J0F93_RS05175 1108084..1108452 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
J0F93_RS05180 1108611..1108964 - 354 WP_016928845.1 hypothetical protein -
J0F93_RS05185 1109369..1110082 + 714 WP_033641138.1 ABC transporter ATP-binding protein -
J0F93_RS05190 1110079..1110936 + 858 WP_004940309.1 metal ABC transporter permease -
J0F93_RS05195 1110962..1111840 + 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
J0F93_RS05200 1111948..1112088 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
J0F93_RS05205 1112101..1112355 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T195710 WP_004940313.1 NZ_CP071210:c1108034-1107831 [Serratia marcescens subsp. marcescens ATCC 13880]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T195710 NZ_CP094797:c874737-874549 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT195710 WP_004940312.1 NZ_CP071210:c1108452-1108084 [Serratia marcescens subsp. marcescens ATCC 13880]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT195710 NZ_CP094797:c875026-874766 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References