Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4164019..4164688 Replicon chromosome
Accession NZ_CP071208
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S81_jyu2015

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag J0F85_RS19885 Protein ID WP_016929976.1
Coordinates 4164019..4164441 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag J0F85_RS19890 Protein ID WP_004931679.1
Coordinates 4164422..4164688 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F85_RS19865 4159905..4160423 + 519 WP_033639477.1 flavodoxin FldB -
J0F85_RS19870 4160461..4161825 - 1365 WP_033639476.1 cell envelope integrity protein CreD -
J0F85_RS19875 4161906..4163324 - 1419 WP_033639474.1 two-component system sensor histidine kinase CreC -
J0F85_RS19880 4163321..4164019 - 699 WP_033639472.1 two-component system response regulator CreB -
J0F85_RS19885 4164019..4164441 - 423 WP_016929976.1 protein YgfX Toxin
J0F85_RS19890 4164422..4164688 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
J0F85_RS19895 4165009..4166001 + 993 WP_033639470.1 tRNA-modifying protein YgfZ -
J0F85_RS19900 4166040..4166537 - 498 WP_033639468.1 DUF2165 domain-containing protein -
J0F85_RS19905 4166688..4167362 - 675 WP_033639467.1 hemolysin III family protein -
J0F85_RS19910 4167546..4168154 + 609 WP_028127691.1 HD domain-containing protein -
J0F85_RS19915 4168195..4169121 - 927 WP_033639466.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T195706 WP_016929976.1 NZ_CP071208:c4164441-4164019 [Serratia marcescens subsp. marcescens ATCC 13880]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T195706 NZ_CP094795:c2410237-2409971 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAGATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT195706 WP_004931679.1 NZ_CP071208:c4164688-4164422 [Serratia marcescens subsp. marcescens ATCC 13880]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT195706 NZ_CP094795:c2410488-2410237 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References