Detailed information of TA system TA195693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 55069..55604
• Replicon: chromosome
• Accession: NZ_CP071208
• Organism: Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S81_jyu2015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: J0F85_RS00240
• Protein ID: WP_033636570.1
• Coordinates: 55329..55604 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: J0F85_RS00235
• Protein ID: WP_033639076.1
• Coordinates: 55069..55329 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0F85_RS00215	50397..51047	+	651	WP_033639079.1	DcrB-related protein	-
J0F85_RS00220	51083..51688	+	606	WP_004934025.1	glutathione S-transferase	-
J0F85_RS00225	51754..53148	+	1395	WP_033639078.1	L-seryl-tRNA(Sec) selenium transferase	-
J0F85_RS00230	53145..54986	+	1842	WP_033639077.1	selenocysteine-specific translation elongation factor	-
J0F85_RS00235	55069..55329	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
J0F85_RS00240	55329..55604	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J0F85_RS00245	55616..56527	-	912	WP_033639075.1	LysR family transcriptional regulator	-
J0F85_RS00250	56649..57275	+	627	WP_033639074.1	LysE family translocator	-
J0F85_RS00255	57329..58576	-	1248	WP_028127797.1	MFS transporter	-
J0F85_RS00260	58794..59786	+	993	WP_033639073.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T195693 WP_033636570.1 NZ_CP071208:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T195693 NZ_CP094793:347133-347384 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTGGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT195693 WP_033639076.1 NZ_CP071208:55069-55329 [Serratia marcescens subsp. marcescens ATCC 13880]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT195693 NZ_CP094793:347374-347547 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AAGGGGACGAGTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D971