Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4453992..4454587 Replicon chromosome
Accession NZ_CP071204
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S6_jyu2015

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S6LRI1
Locus tag J0G02_RS21245 Protein ID WP_071605322.1
Coordinates 4454333..4454587 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J0G02_RS21240 Protein ID WP_033633573.1
Coordinates 4453992..4454333 (-) Length 114 a.a.

Genomic Context

J0G02_RS21225J0G02_RS21230J0G02_RS21235J0G02_RS21220J0G02_RS21240J0G02_RS21245J0G02_RS21250J0G02_RS21255J0G02_RS21260J0G02_RS21265J0G02_RS21270J0G02_RS21275J0G02_RS21280J0G02_RS21285J0G02_RS21290
Location: 4450458..4452230 (1773 bp)
Type: Others
Protein ID: WP_033639336.1
Location: 4452230..4452916 (687 bp)
Type: Others
Protein ID: WP_060445964.1
Location: 4452913..4453947 (1035 bp)
Type: Others
Protein ID: WP_033639335.1
Location: 4449500..4450315 (816 bp)
Type: Others
Protein ID: WP_033639337.1
Location: 4453992..4454333 (342 bp)
Type: Antitoxin
Protein ID: WP_033633573.1
Location: 4454333..4454587 (255 bp)
Type: Toxin
Protein ID: WP_071605322.1
Location: 4454957..4455154 (198 bp)
Type: Others
Protein ID: WP_126186641.1
Location: 4455202..4455426 (225 bp)
Type: Others
Protein ID: WP_033639333.1
Location: 4455465..4457681 (2217 bp)
Type: Others
Protein ID: WP_033639332.1
Location: 4457678..4457992 (315 bp)
Type: Others
Protein ID: WP_033639331.1
Location: 4458006..4458179 (174 bp)
Type: Others
Protein ID: WP_162531492.1
Location: 4458119..4458343 (225 bp)
Type: Others
Protein ID: WP_033639330.1
Location: 4458343..4458585 (243 bp)
Type: Others
Protein ID: WP_023447523.1
Location: 4458649..4458951 (303 bp)
Type: Others
Protein ID: WP_031221632.1
Location: 4458963..4459142 (180 bp)
Type: Others
Protein ID: WP_072009648.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J0G02_RS212204449500..4450315-816WP_033639337.1GPO family capsid scaffolding protein-
J0G02_RS212254450458..4452230+1773WP_033639336.1terminase ATPase subunit family protein-
J0G02_RS212304452230..4452916+687WP_060445964.1terminase family protein-
J0G02_RS212354452913..4453947+1035WP_033639335.1phage portal protein-
J0G02_RS212404453992..4454333-342WP_033633573.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
J0G02_RS212454454333..4454587-255WP_071605322.1type II toxin-antitoxin system HicA family toxinToxin
J0G02_RS212504454957..4455154-198WP_126186641.1hypothetical protein-
J0G02_RS212554455202..4455426-225WP_033639333.1hypothetical protein-
J0G02_RS212604455465..4457681-2217WP_033639332.1replication endonuclease-
J0G02_RS212654457678..4457992-315WP_033639331.1DUF3850 domain-containing protein-
J0G02_RS212704458006..4458179-174WP_162531492.1hypothetical protein-
J0G02_RS212754458119..4458343-225WP_033639330.1TraR/DksA C4-type zinc finger protein-
J0G02_RS212804458343..4458585-243WP_023447523.1DUF2732 family protein-
J0G02_RS212854458649..4458951-303WP_031221632.1hypothetical protein-
J0G02_RS212904458963..4459142-180WP_072009648.1DUF2724 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphageaac(6')-IcrfaE4372078..4489614117536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9495.97 Da        Isoelectric Point: 11.1073

>T195675 WP_071605322.1 NZ_CP071204:c4454587-4454333 [Serratia marcescens subsp. marcescens ATCC 13880]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

>T195675 NZ_CP094789:449224-449550 [Staphylococcus aureus]
ATGAATTTAGAGATTAATGATTTGTTTAGCGATTTGAAATTGTTGAAAGATAGATTCGAAGATTTAAAGGATAGTCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAAAATCATCGAA
AAGTTTCATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12399.90 Da        Isoelectric Point: 4.5789

>AT195675 WP_033633573.1 NZ_CP071204:c4454333-4453992 [Serratia marcescens subsp. marcescens ATCC 13880]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 342 bp

>AT195675 NZ_CP094789:449012-449221 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGAGAAAAGCACTTAGAATTGATATTGAAGT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1S6LRI1

Antitoxin

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Source
ID
Structure
No matching records found

References