Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4164039..4164708 Replicon chromosome
Accession NZ_CP071202
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S97_jyu2015

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag J0F97_RS19890 Protein ID WP_016929976.1
Coordinates 4164039..4164461 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag J0F97_RS19895 Protein ID WP_004931679.1
Coordinates 4164442..4164708 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0F97_RS19870 4159925..4160443 + 519 WP_033639477.1 flavodoxin FldB -
J0F97_RS19875 4160481..4161845 - 1365 WP_033639476.1 cell envelope integrity protein CreD -
J0F97_RS19880 4161926..4163344 - 1419 WP_033639474.1 two-component system sensor histidine kinase CreC -
J0F97_RS19885 4163341..4164039 - 699 WP_033639472.1 two-component system response regulator CreB -
J0F97_RS19890 4164039..4164461 - 423 WP_016929976.1 protein YgfX Toxin
J0F97_RS19895 4164442..4164708 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
J0F97_RS19900 4165029..4166021 + 993 WP_033639470.1 tRNA-modifying protein YgfZ -
J0F97_RS19905 4166060..4166557 - 498 WP_033639468.1 DUF2165 domain-containing protein -
J0F97_RS19910 4166708..4167382 - 675 WP_033639467.1 hemolysin III family protein -
J0F97_RS19915 4167566..4168174 + 609 WP_028127691.1 HD domain-containing protein -
J0F97_RS19920 4168215..4169141 - 927 WP_033639466.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T195658 WP_016929976.1 NZ_CP071202:c4164461-4164039 [Serratia marcescens subsp. marcescens ATCC 13880]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T195658 NZ_CP094785:449224-449550 [Staphylococcus aureus]
ATGAATTTAGAGATTAATGATTTGTTTAGCGATTTGAAATTGTTGAAAGATAGATTCGAAGATTTAAAGGATAGTCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAAAATCATCGAA
AAGTTTCATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT195658 WP_004931679.1 NZ_CP071202:c4164708-4164442 [Serratia marcescens subsp. marcescens ATCC 13880]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT195658 NZ_CP094785:449012-449221 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGAGAAAAGCACTTAGAATTGATATTGAAGT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References