Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3109189..3109820 Replicon chromosome
Accession NZ_CP071202
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S97_jyu2015

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag J0F97_RS14875 Protein ID WP_033640020.1
Coordinates 3109189..3109587 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J0F97_RS14880 Protein ID WP_033640019.1
Coordinates 3109587..3109820 (-) Length 78 a.a.

Genomic Context

J0F97_RS14850J0F97_RS14855J0F97_RS14860J0F97_RS14865J0F97_RS14870J0F97_RS14875J0F97_RS14880J0F97_RS14885J0F97_RS14890J0F97_RS14895J0F97_RS14900J0F97_RS14905
Location: 3104764..3105138 (375 bp)
Type: Others
Protein ID: WP_033640023.1
Location: 3105131..3105433 (303 bp)
Type: Others
Protein ID: WP_015378258.1
Location: 3105436..3105840 (405 bp)
Type: Others
Protein ID: WP_033640022.1
Location: 3105840..3107918 (2079 bp)
Type: Others
Protein ID: WP_016927291.1
Location: 3107911..3109062 (1152 bp)
Type: Others
Protein ID: WP_033640021.1
Location: 3109189..3109587 (399 bp)
Type: Toxin
Protein ID: WP_033640020.1
Location: 3109587..3109820 (234 bp)
Type: Antitoxin
Protein ID: WP_033640019.1
Location: 3109970..3110614 (645 bp)
Type: Others
Protein ID: WP_004934858.1
Location: 3110625..3111014 (390 bp)
Type: Others
Protein ID: WP_004934862.1
Location: 3111117..3112166 (1050 bp)
Type: Others
Protein ID: WP_033640018.1
Location: 3112166..3113038 (873 bp)
Type: Others
Protein ID: WP_025159837.1
Location: 3113076..3114692 (1617 bp)
Type: Others
Protein ID: WP_033640017.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J0F97_RS148503104764..3105138+375WP_033640023.1type II toxin-antitoxin system RelE/ParE family toxin-
J0F97_RS148553105131..3105433+303WP_015378258.1DNA-binding transcriptional regulator-
J0F97_RS148603105436..3105840-405WP_033640022.1flagellar protein FlhE-
J0F97_RS148653105840..3107918-2079WP_016927291.1flagellar biosynthesis protein FlhA-
J0F97_RS148703107911..3109062-1152WP_033640021.1flagellar type III secretion system protein FlhB-
J0F97_RS148753109189..3109587-399WP_033640020.1type II toxin-antitoxin system VapC family toxinToxin
J0F97_RS148803109587..3109820-234WP_033640019.1antitoxinAntitoxin
J0F97_RS148853109970..3110614-645WP_004934858.1protein phosphatase CheZ-
J0F97_RS148903110625..3111014-390WP_004934862.1chemotaxis response regulator CheY-
J0F97_RS148953111117..3112166-1050WP_033640018.1chemotaxis response regulator protein-glutamate methylesterase-
J0F97_RS149003112166..3113038-873WP_025159837.1protein-glutamate O-methyltransferase CheR-
J0F97_RS149053113076..3114692-1617WP_033640017.1Tar ligand binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T195656 WP_033640020.1 NZ_CP071202:c3109587-3109189 [Serratia marcescens subsp. marcescens ATCC 13880]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T195656 NZ_CP094783:c2426881-2426615 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATAGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8799.82 Da        Isoelectric Point: 5.0789

>AT195656 WP_033640019.1 NZ_CP071202:c3109820-3109587 [Serratia marcescens subsp. marcescens ATCC 13880]
MTLGSVFTNNRTQAVRLPAEARFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREAF

Download         Length: 234 bp

>AT195656 NZ_CP094783:c2427132-2426881 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAATTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5C7D7C3

Antitoxin

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Source
ID
Structure
No matching records found

References