Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4164017..4164686 Replicon chromosome
Accession NZ_CP071198
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S68_jyu2015

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag J0G08_RS19885 Protein ID WP_016929976.1
Coordinates 4164017..4164439 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag J0G08_RS19890 Protein ID WP_004931679.1
Coordinates 4164420..4164686 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G08_RS19865 4159903..4160421 + 519 WP_033639477.1 flavodoxin FldB -
J0G08_RS19870 4160459..4161823 - 1365 WP_033639476.1 cell envelope integrity protein CreD -
J0G08_RS19875 4161904..4163322 - 1419 WP_033639474.1 two-component system sensor histidine kinase CreC -
J0G08_RS19880 4163319..4164017 - 699 WP_033639472.1 two-component system response regulator CreB -
J0G08_RS19885 4164017..4164439 - 423 WP_016929976.1 protein YgfX Toxin
J0G08_RS19890 4164420..4164686 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
J0G08_RS19895 4165007..4165999 + 993 WP_033639470.1 tRNA-modifying protein YgfZ -
J0G08_RS19900 4166038..4166535 - 498 WP_033639468.1 DUF2165 domain-containing protein -
J0G08_RS19905 4166686..4167360 - 675 WP_033639467.1 hemolysin III family protein -
J0G08_RS19910 4167544..4168152 + 609 WP_028127691.1 HD domain-containing protein -
J0G08_RS19915 4168193..4169119 - 927 WP_033639466.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T195626 WP_016929976.1 NZ_CP071198:c4164439-4164017 [Serratia marcescens subsp. marcescens ATCC 13880]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T195626 NZ_CP094778:c2176707-2176345 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT195626 WP_004931679.1 NZ_CP071198:c4164686-4164420 [Serratia marcescens subsp. marcescens ATCC 13880]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT195626 NZ_CP094778:c2176874-2176704 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References