Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3109169..3109800 Replicon chromosome
Accession NZ_CP071196
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S54_jyu2015

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag J0G03_RS14875 Protein ID WP_033640020.1
Coordinates 3109169..3109567 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J0G03_RS14880 Protein ID WP_033640019.1
Coordinates 3109567..3109800 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G03_RS14850 3104744..3105118 + 375 WP_033640023.1 type II toxin-antitoxin system RelE/ParE family toxin -
J0G03_RS14855 3105111..3105413 + 303 WP_015378258.1 DNA-binding transcriptional regulator -
J0G03_RS14860 3105416..3105820 - 405 WP_033640022.1 flagellar protein FlhE -
J0G03_RS14865 3105820..3107898 - 2079 WP_016927291.1 flagellar biosynthesis protein FlhA -
J0G03_RS14870 3107891..3109042 - 1152 WP_033640021.1 flagellar type III secretion system protein FlhB -
J0G03_RS14875 3109169..3109567 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
J0G03_RS14880 3109567..3109800 - 234 WP_033640019.1 antitoxin Antitoxin
J0G03_RS14885 3109950..3110594 - 645 WP_004934858.1 protein phosphatase CheZ -
J0G03_RS14890 3110605..3110994 - 390 WP_004934862.1 chemotaxis response regulator CheY -
J0G03_RS14895 3111097..3112146 - 1050 WP_033640018.1 chemotaxis response regulator protein-glutamate methylesterase -
J0G03_RS14900 3112146..3113018 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
J0G03_RS14905 3113056..3114672 - 1617 WP_033640017.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T195608 WP_033640020.1 NZ_CP071196:c3109567-3109169 [Serratia marcescens subsp. marcescens ATCC 13880]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T195608 NZ_CP094773:1887696-1887791 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8799.82 Da        Isoelectric Point: 5.0789

>AT195608 WP_033640019.1 NZ_CP071196:c3109800-3109567 [Serratia marcescens subsp. marcescens ATCC 13880]
MTLGSVFTNNRTQAVRLPAEARFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREAF

Download         Length: 234 bp

>AT195608 NZ_CP094773:c1887876-1887819 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure

References