Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1601561..1602108 Replicon chromosome
Accession NZ_CP071196
Organism Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S54_jyu2015

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag J0G03_RS07645 Protein ID WP_025302144.1
Coordinates 1601800..1602108 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag J0G03_RS07640 Protein ID WP_033633717.1
Coordinates 1601561..1601797 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G03_RS07625 1598047..1599582 + 1536 WP_033640885.1 glutathione ABC transporter substrate-binding protein GsiB -
J0G03_RS07630 1599635..1600555 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
J0G03_RS07635 1600565..1601473 + 909 WP_181817231.1 glutathione ABC transporter permease GsiD -
J0G03_RS07640 1601561..1601797 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J0G03_RS07645 1601800..1602108 + 309 WP_025302144.1 CcdB family protein Toxin
J0G03_RS07650 1602145..1602987 - 843 WP_015377214.1 S-formylglutathione hydrolase -
J0G03_RS07655 1603002..1604126 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
J0G03_RS07660 1604156..1605076 - 921 WP_033640884.1 LysR family transcriptional regulator -
J0G03_RS07665 1605182..1606339 + 1158 WP_033640883.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T195599 WP_025302144.1 NZ_CP071196:1601800-1602108 [Serratia marcescens subsp. marcescens ATCC 13880]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T195599 NZ_CP094772:c2155054-2154845 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT195599 WP_033633717.1 NZ_CP071196:1601561-1601797 [Serratia marcescens subsp. marcescens ATCC 13880]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT195599 NZ_CP094772:c2155359-2155066 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380ADA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References