Detailed information of TA system TA195576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3110447..3111078
• Replicon: chromosome
• Accession: NZ_CP071192
• Organism: Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S60_jyu2015

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7D7C3
• Locus tag: J0F87_RS14885
• Protein ID: WP_033640020.1
• Coordinates: 3110447..3110845 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J0F87_RS14890
• Protein ID: WP_033640019.1
• Coordinates: 3110845..3111078 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0F87_RS14860	3106022..3106396	+	375	WP_033640023.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J0F87_RS14865	3106389..3106691	+	303	WP_015378258.1	DNA-binding transcriptional regulator	-
J0F87_RS14870	3106694..3107098	-	405	WP_033640022.1	flagellar protein FlhE	-
J0F87_RS14875	3107098..3109176	-	2079	WP_016927291.1	flagellar biosynthesis protein FlhA	-
J0F87_RS14880	3109169..3110320	-	1152	WP_033640021.1	flagellar type III secretion system protein FlhB	-
J0F87_RS14885	3110447..3110845	-	399	WP_033640020.1	type II toxin-antitoxin system VapC family toxin	Toxin
J0F87_RS14890	3110845..3111078	-	234	WP_033640019.1	antitoxin	Antitoxin
J0F87_RS14895	3111228..3111872	-	645	WP_004934858.1	protein phosphatase CheZ	-
J0F87_RS14900	3111883..3112272	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
J0F87_RS14905	3112375..3113424	-	1050	WP_033640018.1	chemotaxis response regulator protein-glutamate methylesterase	-
J0F87_RS14910	3113424..3114296	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
J0F87_RS14915	3114334..3115950	-	1617	WP_033640017.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14918.11 Da
• Isoelectric Point: 8.4955

>T195576 WP_033640020.1 NZ_CP071192:c3110845-3110447 [Serratia marcescens subsp. marcescens ATCC 13880]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Nucleotide

• Length: 399 bp

>T195576 NZ_CP094765:c2562242-2561976 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8799.82 Da
• Isoelectric Point: 5.0789

>AT195576 WP_033640019.1 NZ_CP071192:c3111078-3110845 [Serratia marcescens subsp. marcescens ATCC 13880]
MTLGSVFTNNRTQAVRLPAEARFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREAF

Nucleotide

• Length: 234 bp

>AT195576 NZ_CP094765:c2562493-2562242 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• AlphaFold DB: A0A5C7D7C3