Detailed information of TA system TA195544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3109177..3109808
• Replicon: chromosome
• Accession: NZ_CP071188
• Organism: Serratia marcescens subsp. marcescens ATCC 13880 substr. Sm_S94_jyu2015

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7D7C3
• Locus tag: J0F99_RS14875
• Protein ID: WP_033640020.1
• Coordinates: 3109177..3109575 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J0F99_RS14880
• Protein ID: WP_033640019.1
• Coordinates: 3109575..3109808 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0F99_RS14850	3104752..3105126	+	375	WP_033640023.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J0F99_RS14855	3105119..3105421	+	303	WP_015378258.1	DNA-binding transcriptional regulator	-
J0F99_RS14860	3105424..3105828	-	405	WP_033640022.1	flagellar protein FlhE	-
J0F99_RS14865	3105828..3107906	-	2079	WP_016927291.1	flagellar biosynthesis protein FlhA	-
J0F99_RS14870	3107899..3109050	-	1152	WP_033640021.1	flagellar type III secretion system protein FlhB	-
J0F99_RS14875	3109177..3109575	-	399	WP_033640020.1	type II toxin-antitoxin system VapC family toxin	Toxin
J0F99_RS14880	3109575..3109808	-	234	WP_033640019.1	antitoxin	Antitoxin
J0F99_RS14885	3109958..3110602	-	645	WP_004934858.1	protein phosphatase CheZ	-
J0F99_RS14890	3110613..3111002	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
J0F99_RS14895	3111105..3112154	-	1050	WP_033640018.1	chemotaxis response regulator protein-glutamate methylesterase	-
J0F99_RS14900	3112154..3113026	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
J0F99_RS14905	3113064..3114680	-	1617	WP_033640017.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14918.11 Da
• Isoelectric Point: 8.4955

>T195544 WP_033640020.1 NZ_CP071188:c3109575-3109177 [Serratia marcescens subsp. marcescens ATCC 13880]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Nucleotide

• Length: 399 bp

>T195544 NZ_CP094758:c863539-863351 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8799.82 Da
• Isoelectric Point: 5.0789

>AT195544 WP_033640019.1 NZ_CP071188:c3109808-3109575 [Serratia marcescens subsp. marcescens ATCC 13880]
MTLGSVFTNNRTQAVRLPAEARFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREAF

Nucleotide

• Length: 234 bp

>AT195544 NZ_CP094758:c863828-863568 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A5C7D7C3