Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4584612..4585239 Replicon chromosome
Accession NZ_CP071182
Organism Alicyclobacillus ferrooxydans strain S30H14

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JZ786_RS21700 Protein ID WP_206656358.1
Coordinates 4584612..4584962 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JZ786_RS21705 Protein ID WP_206656359.1
Coordinates 4584967..4585239 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ786_RS21665 4580745..4581407 - 663 WP_206656351.1 DUF190 domain-containing protein -
JZ786_RS21670 4581575..4581736 - 162 WP_206656352.1 hypothetical protein -
JZ786_RS21675 4581993..4582550 + 558 WP_206656353.1 c-type cytochrome -
JZ786_RS21680 4582854..4583468 + 615 WP_206656354.1 VTT domain-containing protein -
JZ786_RS21685 4583498..4583752 + 255 WP_206656355.1 DUF1450 domain-containing protein -
JZ786_RS21690 4583864..4584082 - 219 WP_206656356.1 DUF2922 family protein -
JZ786_RS21695 4584134..4584373 - 240 WP_206656357.1 DUF1659 domain-containing protein -
JZ786_RS21700 4584612..4584962 - 351 WP_206656358.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JZ786_RS21705 4584967..4585239 - 273 WP_206656359.1 ribbon-helix-helix protein, CopG family Antitoxin
JZ786_RS21710 4585351..4586553 - 1203 WP_206656360.1 alanine racemase -
JZ786_RS21715 4586689..4587687 - 999 WP_206656361.1 outer membrane lipoprotein carrier protein LolA -
JZ786_RS21720 4587740..4589197 - 1458 WP_206656362.1 NAD(P)H-hydrate dehydratase -
JZ786_RS21725 4589269..4589643 - 375 WP_206656363.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12919.86 Da        Isoelectric Point: 5.6328

>T195532 WP_206656358.1 NZ_CP071182:c4584962-4584612 [Alicyclobacillus ferrooxydans]
MNVKRGDIFFADLSPVVGSEQGGFRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEVQGREGGLERDSVILLEQI
RTIDKQRLTDKITHLDDEMMRHVNEALQISLGLVDF

Download         Length: 351 bp

>T195532 NZ_CP094755:1873243-1873338 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10332.85 Da        Isoelectric Point: 8.5778

>AT195532 WP_206656359.1 NZ_CP071182:c4585239-4584967 [Alicyclobacillus ferrooxydans]
VSEKKRIVLSISQQLLEQVDGIAQRRQTNRSEVIREAMRQYVVERRKDDIRIALQQGYLEMAPINLRMASEAFFVEQEAG
GTVERLVSGV

Download         Length: 273 bp

>AT195532 NZ_CP094755:c1873423-1873366 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References