Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 33029..33522 Replicon plasmid pLI47-2
Accession NZ_CP071181
Organism Listeria innocua strain LI47

Toxin (Protein)


Gene name relE Uniprot ID A0A686CL10
Locus tag JZX95_RS15570 Protein ID WP_031642448.1
Coordinates 33029..33304 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A823KSU7
Locus tag JZX95_RS15575 Protein ID WP_061691475.1
Coordinates 33301..33522 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZX95_RS15550 28099..30045 - 1947 WP_211088794.1 ATP-binding protein -
JZX95_RS15555 30042..30581 - 540 WP_049961604.1 hypothetical protein -
JZX95_RS15560 30583..30855 - 273 WP_031642446.1 DUF5592 family protein -
JZX95_RS15565 30872..32791 - 1920 WP_061691474.1 hypothetical protein -
JZX95_RS15570 33029..33304 - 276 WP_031642448.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZX95_RS15575 33301..33522 - 222 WP_061691475.1 DUF6290 family protein Antitoxin
JZX95_RS15580 33605..35929 - 2325 WP_061691476.1 type IV secretory system conjugative DNA transfer family protein -
JZX95_RS15585 35933..36484 - 552 WP_031642452.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..52798 52798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-89)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10899.55 Da        Isoelectric Point: 10.2899

>T195531 WP_031642448.1 NZ_CP071181:c33304-33029 [Listeria innocua]
MSKHFHVRFEKEAQKVLKKMDRFQAKLILSWIEKHIEGTDDPRQHGKSLVGNRSGQWRYRVGDYRLIAEIQDNEVIVLIL
NIGHRRDIYDK

Download         Length: 276 bp

>T195531 NZ_CP094755:875578-875904 [Staphylococcus aureus]
ATGAATTTAGAGATTAATGATTTGTTTAGCGATTTGAAATTGTTGAAAGATAGATTCGAAGATTTAAAGGATAATCATGG
TTGGCATTTTGATAATTTTTATCCTCATGAACCTAATCATGTTTTAAATAAAACCGAAGCGATTAAAGAAGGACTTTCTT
ATCACGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTCATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8475.69 Da        Isoelectric Point: 4.6536

>AT195531 WP_061691475.1 NZ_CP071181:c33522-33301 [Listeria innocua]
MTTITFRVSDKEKAFIQEMAKLNGISISELSRKQIIEGLEDQIDLQSYERAIKAHQVKDESISFDEMKKELEL

Download         Length: 222 bp

>AT195531 NZ_CP094755:875366-875575 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAGGTATTAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACTGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATATTGAAGT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A686CL10

Antitoxin

Source ID Structure
AlphaFold DB A0A823KSU7

References