Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3794201..3794858 Replicon chromosome
Accession NZ_CP071178
Organism Enterobacter kobei strain CDL29

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag JZY03_RS17775 Protein ID WP_014885136.1
Coordinates 3794201..3794611 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag JZY03_RS17780 Protein ID WP_010435322.1
Coordinates 3794592..3794858 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY03_RS17755 (JZY03_17705) 3790195..3791928 - 1734 WP_032635612.1 single-stranded-DNA-specific exonuclease RecJ -
JZY03_RS17760 (JZY03_17710) 3791934..3792647 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JZY03_RS17765 (JZY03_17715) 3792676..3793572 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
JZY03_RS17770 (JZY03_17720) 3793674..3794195 + 522 WP_047344477.1 flavodoxin FldB -
JZY03_RS17775 (JZY03_17725) 3794201..3794611 - 411 WP_014885136.1 protein YgfX Toxin
JZY03_RS17780 (JZY03_17730) 3794592..3794858 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
JZY03_RS17785 (JZY03_17735) 3795153..3796133 + 981 WP_014885137.1 tRNA-modifying protein YgfZ -
JZY03_RS17790 (JZY03_17740) 3796218..3796877 - 660 WP_023331242.1 hemolysin III family protein -
JZY03_RS17795 (JZY03_17745) 3797143..3797874 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
JZY03_RS17800 (JZY03_17750) 3797991..3799424 + 1434 WP_014885140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T195527 WP_014885136.1 NZ_CP071178:c3794611-3794201 [Enterobacter kobei]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T195527 NZ_CP094752:c2501476-2501369 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT195527 WP_010435322.1 NZ_CP071178:c3794858-3794592 [Enterobacter kobei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT195527 NZ_CP094752:2501292-2501352 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References