Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2875338..2875928 Replicon chromosome
Accession NZ_CP071178
Organism Enterobacter kobei strain CDL29

Toxin (Protein)


Gene name pemK Uniprot ID A0A8B2Y1G2
Locus tag JZY03_RS13605 Protein ID WP_045134957.1
Coordinates 2875338..2875670 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JZY03_RS13610 Protein ID WP_045134956.1
Coordinates 2875671..2875928 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY03_RS13590 (JZY03_13565) 2871502..2872827 + 1326 WP_045134958.1 SidA/IucD/PvdA family monooxygenase -
JZY03_RS13595 (JZY03_13570) 2872854..2875043 + 2190 WP_023330840.1 TonB-dependent siderophore receptor -
JZY03_RS13605 (JZY03_13580) 2875338..2875670 - 333 WP_045134957.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JZY03_RS13610 (JZY03_13585) 2875671..2875928 - 258 WP_045134956.1 antitoxin Antitoxin
JZY03_RS13615 (JZY03_13590) 2876276..2876482 - 207 WP_045134955.1 helix-turn-helix transcriptional regulator -
JZY03_RS13620 (JZY03_13595) 2876479..2876946 - 468 Protein_2668 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11785.63 Da        Isoelectric Point: 10.5834

>T195525 WP_045134957.1 NZ_CP071178:c2875670-2875338 [Enterobacter kobei]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSKASFNKLTRLPVVVPITSGGNFARTAGFTVSLDGAGTKTMGAIRCDQPRTI
DMAARSGKRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

>T195525 NZ_CP094752:c2213123-2213019 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9311.83 Da        Isoelectric Point: 4.7512

>AT195525 WP_045134956.1 NZ_CP071178:c2875928-2875671 [Enterobacter kobei]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTINNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEGREWIDAPVV
GKEIL

Download         Length: 258 bp

>AT195525 NZ_CP094752:2212926-2212964 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B2Y1G2

Antitoxin

Source ID Structure

References