195506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 366425..366959 Replicon chromosome
Accession NZ_CP071176
Organism Enterococcus faecalis strain L18

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag JZP79_RS01935 Protein ID WP_002360769.1
Coordinates 366684..366959 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag JZP79_RS01930 Protein ID WP_002369771.1
Coordinates 366425..366691 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZP79_RS01895 362283..363068 + 786 WP_002360778.1 replication-relaxation family protein -
JZP79_RS01900 363074..363562 + 489 WP_002415813.1 hypothetical protein -
JZP79_RS01905 364154..364420 + 267 WP_002377947.1 hypothetical protein -
JZP79_RS01910 364453..364953 + 501 WP_002360775.1 DnaJ domain-containing protein -
JZP79_RS01915 364966..365214 + 249 WP_002360773.1 DUF3850 domain-containing protein -
JZP79_RS01920 365290..365706 + 417 WP_010710134.1 single-stranded DNA-binding protein -
JZP79_RS01925 365730..366314 + 585 WP_002377949.1 thermonuclease family protein -
JZP79_RS01930 366425..366691 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JZP79_RS01935 366684..366959 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
JZP79_RS01940 367150..367830 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JZP79_RS01945 367998..368606 + 609 WP_002361211.1 response regulator transcription factor -
JZP79_RS01950 369070..369909 + 840 WP_002367965.1 aldo/keto reductase -
JZP79_RS01955 369932..370414 + 483 WP_002397525.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF0485 341050..385829 44779
- flank IS/Tn - - 367150..367830 680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T195506 WP_002360769.1 NZ_CP071176:366684-366959 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T195506 NZ_CP094747:c2190751-2190542 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT195506 WP_002369771.1 NZ_CP071176:366425-366691 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT195506 NZ_CP094747:c2191056-2190763 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References