Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 2400954..2401488 Replicon chromosome
Accession NZ_CP071172
Organism Enterococcus faecalis strain L13

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag JZP77_RS11540 Protein ID WP_002360769.1
Coordinates 2400954..2401229 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag JZP77_RS11545 Protein ID WP_002369771.1
Coordinates 2401222..2401488 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZP77_RS11520 2397499..2397981 - 483 WP_002397525.1 VOC family protein -
JZP77_RS11525 2398004..2398843 - 840 WP_002367965.1 aldo/keto reductase -
JZP77_RS11530 2399307..2399915 - 609 WP_002361211.1 response regulator transcription factor -
JZP77_RS11535 2400083..2400763 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JZP77_RS11540 2400954..2401229 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
JZP77_RS11545 2401222..2401488 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JZP77_RS11550 2401599..2402183 - 585 WP_002377949.1 thermonuclease family protein -
JZP77_RS11555 2402207..2402623 - 417 WP_010710134.1 single-stranded DNA-binding protein -
JZP77_RS11560 2402699..2402947 - 249 WP_002360773.1 DUF3850 domain-containing protein -
JZP77_RS11565 2402960..2403460 - 501 WP_002360775.1 DnaJ domain-containing protein -
JZP77_RS11570 2403493..2403759 - 267 WP_002377947.1 hypothetical protein -
JZP77_RS11575 2404351..2404839 - 489 WP_002415813.1 hypothetical protein -
JZP77_RS11580 2404845..2405630 - 786 WP_002360778.1 replication-relaxation family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2359615..2414510 54895
- flank IS/Tn - - 2400083..2400763 680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T195501 WP_002360769.1 NZ_CP071172:c2401229-2400954 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T195501 NZ_CP094745:c2177192-2176983 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT195501 WP_002369771.1 NZ_CP071172:c2401488-2401222 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT195501 NZ_CP094745:c2177497-2177204 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References