Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-DinJ |
Location | 2400954..2401488 | Replicon | chromosome |
Accession | NZ_CP071172 | ||
Organism | Enterococcus faecalis strain L13 |
Toxin (Protein)
Gene name | relE | Uniprot ID | R3JX52 |
Locus tag | JZP77_RS11540 | Protein ID | WP_002360769.1 |
Coordinates | 2400954..2401229 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | R3H6P0 |
Locus tag | JZP77_RS11545 | Protein ID | WP_002369771.1 |
Coordinates | 2401222..2401488 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JZP77_RS11520 | 2397499..2397981 | - | 483 | WP_002397525.1 | VOC family protein | - |
JZP77_RS11525 | 2398004..2398843 | - | 840 | WP_002367965.1 | aldo/keto reductase | - |
JZP77_RS11530 | 2399307..2399915 | - | 609 | WP_002361211.1 | response regulator transcription factor | - |
JZP77_RS11535 | 2400083..2400763 | + | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
JZP77_RS11540 | 2400954..2401229 | - | 276 | WP_002360769.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
JZP77_RS11545 | 2401222..2401488 | - | 267 | WP_002369771.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
JZP77_RS11550 | 2401599..2402183 | - | 585 | WP_002377949.1 | thermonuclease family protein | - |
JZP77_RS11555 | 2402207..2402623 | - | 417 | WP_010710134.1 | single-stranded DNA-binding protein | - |
JZP77_RS11560 | 2402699..2402947 | - | 249 | WP_002360773.1 | DUF3850 domain-containing protein | - |
JZP77_RS11565 | 2402960..2403460 | - | 501 | WP_002360775.1 | DnaJ domain-containing protein | - |
JZP77_RS11570 | 2403493..2403759 | - | 267 | WP_002377947.1 | hypothetical protein | - |
JZP77_RS11575 | 2404351..2404839 | - | 489 | WP_002415813.1 | hypothetical protein | - |
JZP77_RS11580 | 2404845..2405630 | - | 786 | WP_002360778.1 | replication-relaxation family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 2359615..2414510 | 54895 | |
- | flank | IS/Tn | - | - | 2400083..2400763 | 680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10732.58 Da Isoelectric Point: 9.6918
>T195501 WP_002360769.1 NZ_CP071172:c2401229-2400954 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
Download Length: 276 bp
>T195501 NZ_CP094745:c2177192-2176983 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9772.09 Da Isoelectric Point: 4.4791
>AT195501 WP_002369771.1 NZ_CP071172:c2401488-2401222 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
Download Length: 267 bp
>AT195501 NZ_CP094745:c2177497-2177204 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AEA7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AED7 |