Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4115309..4116119 Replicon chromosome
Accession NZ_CP071150
Organism Klebsiella pneumoniae strain IRQBAS102c

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag JZ790_RS20115 Protein ID WP_004178461.1
Coordinates 4115586..4116119 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JZ790_RS20110 Protein ID WP_002887278.1
Coordinates 4115309..4115575 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ790_RS20090 4111180..4111524 - 345 WP_048266266.1 cation efflux system protein CusF -
JZ790_RS20095 4111542..4112927 - 1386 WP_087793843.1 efflux transporter outer membrane subunit -
JZ790_RS20100 4113100..4113783 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
JZ790_RS20105 4113773..4115206 + 1434 WP_023280821.1 Cu(+)/Ag(+) sensor histidine kinase -
JZ790_RS20110 4115309..4115575 + 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JZ790_RS20115 4115586..4116119 + 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
JZ790_RS20120 4116167..4117288 - 1122 WP_009309849.1 cupin domain-containing protein -
JZ790_RS20125 4118146..4118463 + 318 WP_002887322.1 hypothetical protein -
JZ790_RS20130 4118504..4119628 - 1125 WP_004894561.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T195491 WP_004178461.1 NZ_CP071150:4115586-4116119 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T195491 NZ_CP094743:c872603-872415 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT195491 WP_002887278.1 NZ_CP071150:4115309-4115575 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT195491 NZ_CP094743:c872892-872632 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References