Detailed information of TA system TA195486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2409707..2411295
• Replicon: chromosome
• Accession: NZ_CP071150
• Organism: Klebsiella pneumoniae strain IRQBAS102c

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: J2LTC9
• Locus tag: JZ790_RS11860
• Protein ID: WP_004148372.1
• Coordinates: 2409707..2411029 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JZ790_RS11865
• Protein ID: WP_004176198.1
• Coordinates: 2411029..2411295 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZ790_RS11845	2404763..2407264	+	2502	WP_040025883.1	fimbrial biogenesis outer membrane usher protein	-
JZ790_RS11850	2407252..2408256	+	1005	WP_040025882.1	type 1 fimbrial protein	-
JZ790_RS11855	2408398..2409690	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
JZ790_RS11860	2409707..2411029	-	1323	WP_004148372.1	type II toxin-antitoxin system HipA family toxin	Toxin
JZ790_RS11865	2411029..2411295	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JZ790_RS11870	2411560..2411886	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
JZ790_RS11875	2411883..2412383	-	501	WP_020804988.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JZ790_RS11880	2412361..2413740	-	1380	WP_206552300.1	purine/pyrimidine permease	-
JZ790_RS11885	2414086..2415240	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
JZ790_RS11890	2415221..2416144	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49127.45 Da
• Isoelectric Point: 7.5357

>T195486 WP_004148372.1 NZ_CP071150:c2411029-2409707 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSLRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T195486 NZ_CP094741:836115-836468 [Staphylococcus chromogenes]
ATGAAGCGTGGCGATGTTTATTTAGCAGATTTATCACCAGTACAAGGGTCAGAGCAAGGGGGAGTCAGACCTGTCGTTAT
TATTCAAAATGATACTGGTAATAAATACAGTCCGACCGTGATTGTTGCAGCGATTACAGGTCGCATCAATAAAGCGAAAA
TTCCAACGCATGTCGAAATTGAAAAGAAAAAATATAAACTCGACAAAGATTCTGTTATTTTGTTAGAACAAATTAGAACA
GTCGATAAAAAGAGGCTTAAAGAAAAGCTCACCTTTCTTTCTGATAAAAAGATGAGAGAAGTCAATGCGGCACTTGGAAT
TAGCTTAGGATTGCACATGAATCAACACAAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT195486 WP_004176198.1 NZ_CP071150:c2411295-2411029 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT195486 NZ_CP094741:835944-836114 [Staphylococcus chromogenes]
ATGTCAGCATTCAATCAAACAAGAGTGAAAAGTTTAGAGCAATCTTTGAAAGAGGGGTATGTTCAGATGGCAGATTTAAA
TCTCTCCCTAGCAACAGAAGCATACTCTGTCGAATGTGAAGCATGTGATTGCAACGAATCACACTTACTTTCTAACCACA
AGGATGACTAA

Structures

Toxin

• AlphaFold DB: J2LTC9