Detailed information of TA system TA195474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB(antitoxin)
• Location: 2146693..2147308
• Replicon: chromosome
• Accession: NZ_CP071148
• Organism: Streptococcus equi subsp. equi strain 470_001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C0M8Y9
• Locus tag: JZI44_RS10305
• Protein ID: WP_012680125.1
• Coordinates: 2146693..2147031 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C0M8Z0
• Locus tag: JZI44_RS10310
• Protein ID: WP_012680126.1
• Coordinates: 2147021..2147308 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZI44_RS10285 (JZI44_10285)	2142752..2143762	+	1011	WP_012680123.1	UDP-glucose 4-epimerase GalE	-
JZI44_RS10290 (JZI44_10290)	2143839..2144882	+	1044	WP_012680124.1	aldose epimerase family protein	-
JZI44_RS11135	2145077..2145391	+	315	Protein_1996	IS200/IS605 family transposase	-
JZI44_RS11140	2145538..2146101	+	564	Protein_1997	transposase	-
JZI44_RS10305 (JZI44_10305)	2146693..2147031	-	339	WP_012680125.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JZI44_RS10310 (JZI44_10310)	2147021..2147308	-	288	WP_012680126.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JZI44_RS10315 (JZI44_10315)	2147670..2149121	-	1452	WP_012680127.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (11-91)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13203.98 Da
• Isoelectric Point: 4.6787

>T195474 WP_012680125.1 NZ_CP071148:c2147031-2146693 [Streptococcus equi subsp. equi]
MAYDIYISNKAEQDLDEIYNYYLTEFSHSSAQKVIESLQSAISILEISPEGYVDFDDRVGRKLFPEGQLRMIPSKHFIVF
YLIRQSRVDILRIRSTKTDYLNDLENLFNNIL

Nucleotide

• Length: 339 bp

>T195474 NZ_CP094734:2367420-2367758 [Staphylococcus delphini]
ATGAGTATTAAACAATTTGACATCATTTACATTGATTTAAATCCAACTCGCGGTCGTGAAAAACAAAACATCAGACCTTG
TTTAGTGATCAATAACCAAATGATGATTGACGGCACTGAATTTGTTTGGGTTGTACCTATCATAAATCGTGAGTTGCGTT
ATCCAACCGATATAGAACTTAAAACCAAAAAAGGACTCGTGTCTGGCCTGATAGATACAATTCAAATGCGTGCTTTAGAC
TTAAACGCACACCAACATCACTATAAAGATGCATTACAAGACAATCTAAAAAGCAAAGTTTTAAAAGCAATACAAACATA
TTTAAATCCAAACTACTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10977.52 Da
• Isoelectric Point: 4.4777

>AT195474 WP_012680126.1 NZ_CP071148:c2147308-2147021 [Streptococcus equi subsp. equi]
MATLIRDRQYNFRVNTEMMEEAKRILEAKNISVPDALNLFVERVVEEKDLPIKTAEQIRAESFLNELISELDEGYQDILA
GRTKPANEVFSKYGL

Nucleotide

• Length: 288 bp

>AT195474 NZ_CP094734:2367154-2367423 [Staphylococcus delphini]
ATGACTCAAACATTTAACGATGTAAGTAAATCGACCGAACGCATTTTTAAAAACGGAAATAGTCAAGCTATGAGTTTAAG
TAAAAAAACGATTCAATTCGTTGATTTTGAGATTGGCGATACAGTTGAAGTACAAAAAATAAATGGTGGGCTGTTTATTA
CTAAAAAAGAAGTATCTATTGAAGATAGTATCAAAAACTTCTTCCAAAATGGTGGTAAGTATCAAGAATCAGAAGTAGAC
TTCGGCGAAAGTGTGGGTCGTGAAATATGA

Structures

Toxin

• AlphaFold DB: C0M8Y9

Antitoxin

• AlphaFold DB: C0M8Z0