Detailed information of TA system TA195473

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1408943..1410371
• Replicon: chromosome
• Accession: NZ_CP071148
• Organism: Streptococcus equi subsp. equi strain 470_001

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: B6YPW2
• Locus tag: JZI44_RS06765
• Protein ID: WP_012679622.1
• Coordinates: 1408943..1409785 (-)
• Length: 281 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: B6YPW1
• Locus tag: JZI44_RS06770
• Protein ID: WP_012679623.1
• Coordinates: 1409778..1410371 (-)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZI44_RS06750 (JZI44_06750)	1406174..1406920	-	747	WP_050315911.1	hypothetical protein	-
JZI44_RS06755 (JZI44_06755)	1406962..1407513	-	552	WP_012679620.1	hypothetical protein	-
JZI44_RS06760 (JZI44_06760)	1407517..1408857	-	1341	Protein_1324	DNA topoisomerase	-
JZI44_RS06765 (JZI44_06765)	1408943..1409785	-	843	WP_012679622.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JZI44_RS06770 (JZI44_06770)	1409778..1410371	-	594	WP_012679623.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JZI44_RS06775 (JZI44_06775)	1410465..1412006	-	1542	Protein_1327	DUF4366 domain-containing protein	-
JZI44_RS06780 (JZI44_06780)	1412065..1412352	-	288	WP_012679625.1	conjugal transfer protein	-
JZI44_RS06785 (JZI44_06785)	1412365..1414653	-	2289	WP_012679626.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1363710..1427914	64204

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 281 a.a.
• Molecular weight: 32683.90 Da
• Isoelectric Point: 5.9694

>T195473 WP_012679622.1 NZ_CP071148:c1409785-1408943 [Streptococcus equi subsp. equi]
MNKAKLTALCHKVSKEVGLSFNAVMLYYFLESILKKLAGSKYSERFIFKGGFLLSSVVGIDSRSTVDIDFLLRNMQLSEE
NIVQMLNETLKPEEFDDIFYELQNIVPIKEEDQYGGFRANILCKMENIRQIVPLDIATGDVITPHPIDYKYVSSFGEEEI
IIKAYPIETMLAEKIQTIYARGFLNSRSKDYYDLYIIYKLKDKDVNVEILREACRKTFSYRKTEFDIGKIIDLLEKLKIN
EAFLKRWQAYSRKNLYAKDITFEEVLDNGIKMVEKIKNEN

Nucleotide

• Length: 843 bp

>T195473 NZ_CP094734:895344-895697 [Staphylococcus delphini]
ATGAAGCGCGGAGACGTCTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTGGTCAT
TATCCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAATAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23345.76 Da
• Isoelectric Point: 8.6522

>AT195473 WP_012679623.1 NZ_CP071148:c1410371-1409778 [Streptococcus equi subsp. equi]
MNYENKIEKYLKQSGGIITTAYCKENNIPTIYLSRLLKDGRLSKVRKGIYITKDGDYDEYYFFQHQYKKAIFSYETALYL
LGQTDKIPWSIDVTVYNGYKFNEKPNGFNVHYVKKSIYDLGVTQKPTMFGNKVKVYSYERTLCDFIAHKEEMDIEVYVKL
IQSYSSYKERDIHSLYDIAMKMGIENKVREVMEVAYE

Nucleotide

• Length: 594 bp

>AT195473 NZ_CP094734:895173-895343 [Staphylococcus delphini]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTATA
AGGAAGACTAA

Structures

Toxin

• AlphaFold DB: B6YPW2

Antitoxin

• AlphaFold DB: B6YPW1