195472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1029199..1029682 Replicon chromosome
Accession NZ_CP071148
Organism Streptococcus equi subsp. equi strain 470_001

Toxin (Protein)


Gene name relE Uniprot ID C0M6K7
Locus tag JZI44_RS05110 Protein ID WP_012679379.1
Coordinates 1029422..1029682 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4U2B9
Locus tag JZI44_RS05105 Protein ID WP_012515410.1
Coordinates 1029199..1029420 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZI44_RS05085 (JZI44_05085) 1026159..1026440 + 282 WP_050315839.1 hypothetical protein -
JZI44_RS05090 (JZI44_05090) 1026625..1027080 - 456 WP_012679378.1 DUF1694 domain-containing protein -
JZI44_RS05095 (JZI44_05095) 1027311..1028618 + 1308 WP_012515409.1 phosphopyruvate hydratase -
JZI44_RS05100 (JZI44_05100) 1028754..1028990 - 237 Protein_987 ISL3 family transposase -
JZI44_RS05105 (JZI44_05105) 1029199..1029420 + 222 WP_012515410.1 DUF6290 family protein Antitoxin
JZI44_RS05110 (JZI44_05110) 1029422..1029682 + 261 WP_012679379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZI44_RS11015 1029698..1029804 + 107 Protein_990 transcriptional regulator -
JZI44_RS05115 (JZI44_05115) 1030347..1030940 + 594 WP_230197347.1 HAD family hydrolase -
JZI44_RS05120 (JZI44_05120) 1031408..1034188 + 2781 WP_012679382.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10291.85 Da        Isoelectric Point: 9.8245

>T195472 WP_012679379.1 NZ_CP071148:1029422-1029682 [Streptococcus equi subsp. equi]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRKDIY

Download         Length: 261 bp

>T195472 NZ_CP094734:880555-880776 [Staphylococcus delphini]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGAGTGTTGTTATTGATTTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.57 Da        Isoelectric Point: 4.6104

>AT195472 WP_012515410.1 NZ_CP071148:1029199-1029420 [Streptococcus equi subsp. equi]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT195472 NZ_CP094734:880255-880542 [Staphylococcus delphini]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGTTGCATCATGCATAAGATTGACGCAGGGCACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACGTTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C0M6K7

Antitoxin

Source ID Structure
AlphaFold DB A0A380KCN4

References