Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 149357..149840 Replicon chromosome
Accession NZ_CP071145
Organism Streptococcus equi subsp. equi strain 470_007

Toxin (Protein)


Gene name relE Uniprot ID C0M6K7
Locus tag JZI48_RS00650 Protein ID WP_012679379.1
Coordinates 149357..149617 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4U2B9
Locus tag JZI48_RS00655 Protein ID WP_012515410.1
Coordinates 149619..149840 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZI48_RS00640 (JZI48_00640) 144851..147631 - 2781 WP_012679382.1 endonuclease/exonuclease/phosphatase family protein -
JZI48_RS00645 (JZI48_00645) 148099..148692 - 594 WP_230197347.1 HAD family hydrolase -
JZI48_RS10900 149235..149341 - 107 Protein_129 transcriptional regulator -
JZI48_RS00650 (JZI48_00650) 149357..149617 - 261 WP_012679379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZI48_RS00655 (JZI48_00655) 149619..149840 - 222 WP_012515410.1 DUF6290 family protein Antitoxin
JZI48_RS00660 (JZI48_00660) 150049..150285 + 237 Protein_132 ISL3 family transposase -
JZI48_RS00665 (JZI48_00665) 150421..151728 - 1308 WP_012515409.1 phosphopyruvate hydratase -
JZI48_RS00670 (JZI48_00670) 151959..152414 + 456 WP_012679378.1 DUF1694 domain-containing protein -
JZI48_RS00675 (JZI48_00675) 152599..152880 - 282 WP_050315839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10291.85 Da        Isoelectric Point: 9.8245

>T195469 WP_012679379.1 NZ_CP071145:c149617-149357 [Streptococcus equi subsp. equi]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRKDIY

Download         Length: 261 bp

>T195469 NZ_CP094733:1031264-1031443 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.57 Da        Isoelectric Point: 4.6104

>AT195469 WP_012515410.1 NZ_CP071145:c149840-149619 [Streptococcus equi subsp. equi]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT195469 NZ_CP094733:1030641-1031240 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C0M6K7

Antitoxin

Source ID Structure
AlphaFold DB A0A380KCN4

References