Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2115192..2115675 Replicon chromosome
Accession NZ_CP071144
Organism Streptococcus equi subsp. equi strain 470_008

Toxin (Protein)


Gene name relE Uniprot ID C0M6K7
Locus tag JZI59_RS10240 Protein ID WP_012679379.1
Coordinates 2115415..2115675 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4U2B9
Locus tag JZI59_RS10235 Protein ID WP_012515410.1
Coordinates 2115192..2115413 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZI59_RS10215 (JZI59_10215) 2112152..2112433 + 282 WP_050315839.1 hypothetical protein -
JZI59_RS10220 (JZI59_10220) 2112618..2113073 - 456 WP_012679378.1 DUF1694 domain-containing protein -
JZI59_RS10225 (JZI59_10225) 2113304..2114611 + 1308 WP_012515409.1 phosphopyruvate hydratase -
JZI59_RS10230 (JZI59_10230) 2114747..2114983 - 237 Protein_1979 ISL3 family transposase -
JZI59_RS10235 (JZI59_10235) 2115192..2115413 + 222 WP_012515410.1 DUF6290 family protein Antitoxin
JZI59_RS10240 (JZI59_10240) 2115415..2115675 + 261 WP_012679379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZI59_RS11125 2115691..2115797 + 107 Protein_1982 transcriptional regulator -
JZI59_RS10245 (JZI59_10245) 2116340..2116933 + 594 WP_230197347.1 HAD family hydrolase -
JZI59_RS10250 (JZI59_10250) 2117401..2120181 + 2781 WP_012679382.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10291.85 Da        Isoelectric Point: 9.8245

>T195468 WP_012679379.1 NZ_CP071144:2115415-2115675 [Streptococcus equi subsp. equi]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRKDIY

Download         Length: 261 bp

>T195468 NZ_CP094733:884158-884520 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.57 Da        Isoelectric Point: 4.6104

>AT195468 WP_012515410.1 NZ_CP071144:2115192-2115413 [Streptococcus equi subsp. equi]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT195468 NZ_CP094733:883991-884161 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C0M6K7

Antitoxin

Source ID Structure
AlphaFold DB A0A380KCN4

References