Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2049081..2049564 Replicon chromosome
Accession NZ_CP071142
Organism Streptococcus equi subsp. equi strain 489_004

Toxin (Protein)


Gene name relE Uniprot ID C0M6K7
Locus tag JZI57_RS09835 Protein ID WP_012679379.1
Coordinates 2049081..2049341 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4U2B9
Locus tag JZI57_RS09840 Protein ID WP_012515410.1
Coordinates 2049343..2049564 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZI57_RS09825 (JZI57_09825) 2044575..2047355 - 2781 WP_012679382.1 endonuclease/exonuclease/phosphatase family protein -
JZI57_RS09830 (JZI57_09830) 2047823..2048383 - 561 WP_201748351.1 HAD family hydrolase -
JZI57_RS11135 2048959..2049065 - 107 Protein_1902 transcriptional regulator -
JZI57_RS09835 (JZI57_09835) 2049081..2049341 - 261 WP_012679379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZI57_RS09840 (JZI57_09840) 2049343..2049564 - 222 WP_012515410.1 DUF6290 family protein Antitoxin
JZI57_RS09845 (JZI57_09845) 2049773..2050009 + 237 Protein_1905 ISL3 family transposase -
JZI57_RS09850 (JZI57_09850) 2050145..2051452 - 1308 WP_012515409.1 phosphopyruvate hydratase -
JZI57_RS09855 (JZI57_09855) 2051683..2052138 + 456 WP_012679378.1 DUF1694 domain-containing protein -
JZI57_RS09860 (JZI57_09860) 2052323..2052604 - 282 WP_050315839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10291.85 Da        Isoelectric Point: 9.8245

>T195465 WP_012679379.1 NZ_CP071142:c2049341-2049081 [Streptococcus equi subsp. equi]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRKDIY

Download         Length: 261 bp

>T195465 NZ_CP094731:1034966-1035148 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTGACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAGATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAGTCAACCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAACAGTAAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.57 Da        Isoelectric Point: 4.6104

>AT195465 WP_012515410.1 NZ_CP071142:c2049564-2049343 [Streptococcus equi subsp. equi]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT195465 NZ_CP094731:1034343-1034942 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGGGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCAATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAGGGAAAACTGACAATGCAAGTCCTTACGATTGACGAAAATGGCAAACTTGACGTTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGTAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C0M6K7

Antitoxin

Source ID Structure
AlphaFold DB A0A380KCN4

References