Detailed information of TA system TA195464

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1668395..1669823
• Replicon: chromosome
• Accession: NZ_CP071142
• Organism: Streptococcus equi subsp. equi strain 489_004

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: B6YPW2
• Locus tag: JZI57_RS08170
• Protein ID: WP_012679622.1
• Coordinates: 1668981..1669823 (+)
• Length: 281 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: B6YPW1
• Locus tag: JZI57_RS08165
• Protein ID: WP_012679623.1
• Coordinates: 1668395..1668988 (+)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZI57_RS08150 (JZI57_08150)	1664114..1666402	+	2289	WP_012679626.1	CHAP domain-containing protein	-
JZI57_RS08155 (JZI57_08155)	1666415..1666702	+	288	WP_012679625.1	conjugal transfer protein	-
JZI57_RS08160 (JZI57_08160)	1666761..1668302	+	1542	Protein_1565	DUF4366 domain-containing protein	-
JZI57_RS08165 (JZI57_08165)	1668395..1668988	+	594	WP_012679623.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JZI57_RS08170 (JZI57_08170)	1668981..1669823	+	843	WP_012679622.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JZI57_RS08175 (JZI57_08175)	1669909..1671249	+	1341	Protein_1568	DNA topoisomerase	-
JZI57_RS08180 (JZI57_08180)	1671253..1671804	+	552	WP_012679620.1	hypothetical protein	-
JZI57_RS08185 (JZI57_08185)	1671846..1672592	+	747	WP_050315911.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1625236..1684536	59300

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 281 a.a.
• Molecular weight: 32683.90 Da
• Isoelectric Point: 5.9694

>T195464 WP_012679622.1 NZ_CP071142:1668981-1669823 [Streptococcus equi subsp. equi]
MNKAKLTALCHKVSKEVGLSFNAVMLYYFLESILKKLAGSKYSERFIFKGGFLLSSVVGIDSRSTVDIDFLLRNMQLSEE
NIVQMLNETLKPEEFDDIFYELQNIVPIKEEDQYGGFRANILCKMENIRQIVPLDIATGDVITPHPIDYKYVSSFGEEEI
IIKAYPIETMLAEKIQTIYARGFLNSRSKDYYDLYIIYKLKDKDVNVEILREACRKTFSYRKTEFDIGKIIDLLEKLKIN
EAFLKRWQAYSRKNLYAKDITFEEVLDNGIKMVEKIKNEN

Nucleotide

• Length: 843 bp

>T195464 NZ_CP094731:887351-887713 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGATAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGATAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23345.76 Da
• Isoelectric Point: 8.6522

>AT195464 WP_012679623.1 NZ_CP071142:1668395-1668988 [Streptococcus equi subsp. equi]
MNYENKIEKYLKQSGGIITTAYCKENNIPTIYLSRLLKDGRLSKVRKGIYITKDGDYDEYYFFQHQYKKAIFSYETALYL
LGQTDKIPWSIDVTVYNGYKFNEKPNGFNVHYVKKSIYDLGVTQKPTMFGNKVKVYSYERTLCDFIAHKEEMDIEVYVKL
IQSYSSYKERDIHSLYDIAMKMGIENKVREVMEVAYE

Nucleotide

• Length: 594 bp

>AT195464 NZ_CP094731:887184-887354 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAACGAATCACATTTAATATCTAATTCCA
AGAATGAATGA

Structures

Toxin

• AlphaFold DB: B6YPW2

Antitoxin

• AlphaFold DB: B6YPW1