Detailed information of TA system TA195462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5761737..5762262
• Replicon: chromosome
• Accession: NZ_CP071139
• Organism: Streptomyces nojiriensis strain JCM 3382

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JYK04_RS27000
• Protein ID: WP_189732868.1
• Coordinates: 5761737..5762000 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JYK04_RS27005
• Protein ID: WP_189732866.1
• Coordinates: 5761993..5762262 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYK04_RS26980 (JYK04_05428)	5758073..5759068	+	996	WP_189732877.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
JYK04_RS26985 (JYK04_05429)	5759090..5759854	+	765	WP_189732875.1	ROK family protein	-
JYK04_RS26990 (JYK04_05430)	5759864..5760256	-	393	WP_229875013.1	hypothetical protein	-
JYK04_RS26995 (JYK04_05431)	5760521..5761609	+	1089	WP_189732870.1	redox-regulated ATPase YchF	-
JYK04_RS27000 (JYK04_05432)	5761737..5762000	-	264	WP_189732868.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JYK04_RS27005 (JYK04_05433)	5761993..5762262	-	270	WP_189732866.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JYK04_RS27010 (JYK04_05434)	5762540..5762760	+	221	Protein_5360	Txe/YoeB family addiction module toxin	-
JYK04_RS27015 (JYK04_05435)	5762958..5763662	+	705	WP_229874964.1	Crp/Fnr family transcriptional regulator	-
JYK04_RS27020 (JYK04_05436)	5763642..5764157	-	516	WP_229874963.1	DUF5706 domain-containing protein	-
JYK04_RS27025 (JYK04_05437)	5764444..5765283	+	840	WP_189732860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9981.46 Da
• Isoelectric Point: 8.5814

>T195462 WP_189732868.1 NZ_CP071139:c5762000-5761737 [Streptomyces nojiriensis]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELETDPLGLGTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVHET

Nucleotide

• Length: 264 bp

>T195462 NZ_CP094729:1997621-1997809 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAGAGAAGAACGAAAAGAATCTTATCTAGGTTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10349.86 Da
• Isoelectric Point: 4.9572

>AT195462 WP_189732866.1 NZ_CP071139:c5762262-5761993 [Streptomyces nojiriensis]
MTQPLPMESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAIVSIEVLRKYQEWEEREINRIIDERMANPARGIPIENI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT195462 NZ_CP094729:1997339-1997596 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATGTATTCAACTTGATATTCACCATTTTATTTTTTACATTTAACATTCTCATAACCTATAA
CGCAAATATTGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGCTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTATATTATATTTATCCGATT
TTTTATGAATTTGTCTAA