195461

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 3795558..3796087 Replicon chromosome
Accession NZ_CP071139
Organism Streptomyces nojiriensis strain JCM 3382

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JYK04_RS17675 Protein ID WP_081523370.1
Coordinates 3795830..3796087 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JYK04_RS17670 Protein ID WP_030010371.1
Coordinates 3795558..3795833 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYK04_RS17655 (JYK04_03551) 3791714..3793084 - 1371 WP_189747306.1 nitrate/nitrite transporter -
JYK04_RS17660 (JYK04_03552) 3793181..3794146 - 966 WP_189747308.1 LysR family transcriptional regulator -
JYK04_RS17665 (JYK04_03553) 3794241..3795521 + 1281 WP_189747383.1 MFS transporter -
JYK04_RS17670 (JYK04_03554) 3795558..3795833 + 276 WP_030010371.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JYK04_RS17675 (JYK04_03555) 3795830..3796087 + 258 WP_081523370.1 Txe/YoeB family addiction module toxin Toxin
JYK04_RS17685 (JYK04_03557) 3796614..3797099 - 486 WP_030161337.1 SsrA-binding protein SmpB -
JYK04_RS17690 (JYK04_03558) 3797118..3798299 - 1182 WP_189747310.1 S41 family peptidase -
JYK04_RS17695 (JYK04_03559) 3798367..3799338 - 972 WP_189747312.1 permease-like cell division protein FtsX -
JYK04_RS17700 (JYK04_03560) 3799356..3800045 - 690 WP_030011324.1 cell division ATP-binding protein FtsE -
JYK04_RS17705 (JYK04_03561) 3800280..3800471 + 192 WP_030011325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10205.64 Da        Isoelectric Point: 9.8313

>T195461 WP_081523370.1 NZ_CP071139:3795830-3796087 [Streptomyces nojiriensis]
VRSVHFDPAAWEDFLFWLSSDRKMARRITRLIGEIQRDPFTGIGKPEPLKGELTGYWSRRIDDEHRLVYRADDKEVKVLK
ARYHY

Download         Length: 258 bp

>T195461 NZ_CP094729:1006237-1006419 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTGACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAACCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAATAGTAAATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10009.14 Da        Isoelectric Point: 4.3766

>AT195461 WP_030010371.1 NZ_CP071139:3795558-3795833 [Streptomyces nojiriensis]
MSISASEARATLFPLIERVNTDHAPVRITSKSGDAVLMSADDYDSWQETVYLLRSPANAQRLMEAVARDREGASTVVRTL
DELRELAGGEE

Download         Length: 276 bp

>AT195461 NZ_CP094729:1005614-1006213 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAACAATCCAACTACTATTGCAGGATTTCATTTAGGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGACAAATTTATTCAATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAGGGAAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACGTTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACCGGTGCTAATAAACGAGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References