Detailed information of TA system TA195460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1180188..1180938
• Replicon: chromosome
• Accession: NZ_CP071138
• Organism: Mammaliicoccus sciuri strain SSC-7107

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: JTZ62_RS06120
• Protein ID: WP_101494413.1
• Coordinates: 1180831..1180938 (+)
• Length: 36 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A657XLL6
• Locus tag: JTZ62_RS06115
• Protein ID: WP_025904800.1
• Coordinates: 1180188..1180787 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JTZ62_RS06090	1175792..1176553	+	762	WP_049320866.1	acetylglutamate kinase	-
JTZ62_RS06095	1177122..1178249	+	1128	WP_048539836.1	tRNA epoxyqueuosine(34) reductase QueG	-
JTZ62_RS06100	1178253..1178726	+	474	WP_025904798.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JTZ62_RS06105	1178761..1178901	-	141	WP_162841915.1	hypothetical protein	-
JTZ62_RS06110	1178988..1180139	+	1152	WP_179926527.1	N-acetylglucosamine-6-phosphate deacetylase	-
JTZ62_RS06115	1180188..1180787	+	600	WP_025904800.1	glucosamine-6-phosphate isomerase	Antitoxin
JTZ62_RS06120	1180831..1180938	+	108	WP_101494413.1	hypothetical protein	Toxin
JTZ62_RS06125	1181093..1182481	+	1389	WP_065381353.1	class II fumarate hydratase	-
JTZ62_RS06130	1182571..1184097	+	1527	WP_058612561.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4130.43 Da
• Isoelectric Point: 3.7615

>T195460 WP_101494413.1 NZ_CP071138:1180831-1180938 [Mammaliicoccus sciuri]
MVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Nucleotide

• Length: 108 bp

>T195460 NZ_CP094729:858716-859078 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGATAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGATAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22291.16 Da
• Isoelectric Point: 4.8551

>AT195460 WP_025904800.1 NZ_CP071138:1180188-1180787 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT195460 NZ_CP094729:858549-858719 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCCA
AGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A657XLL6